Biologically synthesized metallic nanocarriers for efficient therapy of breast cancer.

IF 2.8 3区 医学 Q2 ONCOLOGY
Expert Review of Anticancer Therapy Pub Date : 2025-08-01 Epub Date: 2025-06-11 DOI:10.1080/14737140.2025.2515977
Saili Jagdale, Rajkumar Samanta, Mahavir Narwade, Niladri Haldar, Rajesh Jadon, Virendra Gajbhiye, Kavita R Gajbhiye
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引用次数: 0

Abstract

Introduction: Breast cancer is one of the most common cancers in women and has a high mortality rate. Current treatment methods, including radiation, chemotherapy, and surgery, have limitations such as surrounding tissue damage and nonspecific toxicity, reducing their effectiveness. As a result, new therapeutic platforms are needed to enhance breast cancer treatment.

Areas covered: Nanoparticles, particularly metallic nanoparticles, have shown significant potential in overcoming the limitations of conventional treatments. These nanoparticles offer advantages such as high loading capacity, biocompatibility, adjustable size, and surface modification flexibility, making them ideal for drug delivery. This review focuses on the synthesis of metallic nanoparticles, emphasizing chemical and green synthesis methods. The green synthesis method has gained attention due to its eco-friendliness, biological safety, and cost-effectiveness. Research advancements in biosynthesized metallic nanoparticles for breast cancer therapy are discussed.

Expert opinion: The use of bio-synthesized magnetic nanoparticles in the treatment of breast cancer shows promise for both cytotoxicity and targeted medication delivery. By increasing anti-tumor immune responses, their optical and magnetic qualities improve immunotherapy's efficacy. Furthermore, It have the potential to provide potent anticancer treatments and stimulate multidisciplinary research to address current obstacles in the treatment of breast cancer, opening up new therapeutic development pathways.

生物合成金属纳米载体有效治疗乳腺癌。
导读:乳腺癌是女性最常见的癌症之一,死亡率很高。目前的治疗方法,包括放疗、化疗和手术,都有局限性,如周围组织损伤和非特异性毒性,降低了它们的有效性。因此,需要新的治疗平台来加强乳腺癌的治疗。涉及领域:纳米颗粒,特别是金属纳米颗粒,在克服常规处理的局限性方面显示出巨大的潜力。这些纳米颗粒具有高负载能力、生物相容性、可调节尺寸和表面修饰灵活性等优点,使其成为药物输送的理想选择。本文综述了金属纳米颗粒的合成,重点介绍了化学合成方法和绿色合成方法。绿色合成方法因其生态友好性、生物安全性和成本效益而受到关注。综述了生物合成金属纳米颗粒治疗乳腺癌的研究进展。专家意见:生物合成磁性纳米颗粒在乳腺癌治疗中的应用显示出细胞毒性和靶向药物传递的前景。通过增强抗肿瘤免疫反应,它们的光学和磁性能提高免疫治疗的疗效。此外,它有可能提供有效的抗癌治疗和刺激多学科研究,以解决目前乳腺癌治疗中的障碍,开辟新的治疗发展途径。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
5.10
自引率
3.00%
发文量
100
审稿时长
4-8 weeks
期刊介绍: Expert Review of Anticancer Therapy (ISSN 1473-7140) provides expert appraisal and commentary on the major trends in cancer care and highlights the performance of new therapeutic and diagnostic approaches. Coverage includes tumor management, novel medicines, anticancer agents and chemotherapy, biological therapy, cancer vaccines, therapeutic indications, biomarkers and diagnostics, and treatment guidelines. All articles are subject to rigorous peer-review, and the journal makes an essential contribution to decision-making in cancer care. Comprehensive coverage in each review is complemented by the unique Expert Review format and includes the following sections: Expert Opinion - a personal view of the data presented in the article, a discussion on the developments that are likely to be important in the future, and the avenues of research likely to become exciting as further studies yield more detailed results Article Highlights – an executive summary of the author’s most critical points.
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