The independent effects of age and sex in performance fatigability profile after a ramp incremental cycling test.

IF 2.7 3区医学 Q2 PHYSIOLOGY

European Journal of Applied Physiology Pub Date : 2025-06-04 DOI:10.1007/s00421-025-05823-0

Rafael A Azevedo, Guillaume Y Millet, Juan M Murias

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引用次数: 0

Abstract

Purpose: To investigate the effects of age and sex in performance fatigability profile after a ramp incremental (RI) test.

Methods: Older females (n = 13; 66 ± 5 yrs) and males (n = 13; 68 ± 4 yrs), and young females (n = 11; 25 ± 5 yrs) and males (n = 12; 25 ± 4 yrs) performed a RI test immediately preceded and followed by performance fatigability assessments that included: knee-extension isometric maximal voluntary contraction (IMVC) and femoral nerve electrical stimuli during and after the IMVC to calculate voluntary activation (VA) and contractile function (e.g., potentiated doublets at 10 and 100 Hz, and single twitches). Maximal oxygen uptake (V̇O₂max) and peak power output (POpeak) were measured.

Results: Young females and males showed greater V̇O₂max and POpeak compared to older counterparts (all p < 0.05). The IMVC declined more in young (females: -27 ± 14%; males: -44 ± 7%) than older (females: -23 ± 9%; males: -26 ± 9%) (p < 0.01), and in males compared to females (p < 0.01). Single twitch declined more in young (females: -43 ± 15%; males: -54 ± 15%) than older participants (females: -33 ± 10%; males: -27 ± 18%) (p = 0.01), without sex differences (p = 0.59). Similar responses were observed for 100 Hz and 10 Hz stimulus for age and sex (all p > 0.05). Voluntary activation was not different (p = 0.11) between young (females: -5 ± 5%; males: -8 ± 6%) and older (females: -7 ± 6%; males: -12 ± 6%), but declined less in females than males (p = 0.03). There was no age × sex interaction for any performance fatigability outcome (all p ≥ 0.06).

Conclusion: Contractile function was more impaired in young than older participants, whereas males showed greater decline in VA than females. There was no combined effect of age and sex in performance fatigability responses.

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年龄和性别对坡道增量循环试验后疲劳性能的独立影响。

目的：探讨年龄和性别对坡道增量（RI）试验后疲劳表现的影响。方法：老年女性(n = 13；66±5岁)和男性(n = 13；68±4岁)，年轻女性(n = 11；25±5岁)和男性(n = 12；25±4年)在疲劳性能评估之前和之后立即进行了RI测试，包括：膝关节伸展等长最大自主收缩（IMVC）和在IMVC期间和之后的股神经电刺激，以计算自主激活（VA）和收缩功能（例如，10和100 Hz的增强双峰，以及单次抽搐）。测定最大摄氧量（V * O2max）和峰值输出功率（poppeak）。结果：年轻女性和男性的vo2max和poppeak均高于年长女性（p均为0.05）。自愿激活在年轻人之间没有差异（p = 0.11）(女性：-5±5%；男性：-8±6%)及以上(女性：-7±6%；男性：-12±6%)，但女性下降幅度小于男性（p = 0.03）。任何性能疲劳指标均无年龄×性别交互作用（p均≥0.06）。结论：年轻人的收缩功能受损程度高于老年人，而男性的收缩功能下降程度高于女性。在表现疲劳反应中没有年龄和性别的综合影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Journal of Applied Physiology 医学-生理学

CiteScore

6.00

自引率

6.70%

发文量

227

审稿时长

3 months

期刊介绍： The European Journal of Applied Physiology (EJAP) aims to promote mechanistic advances in human integrative and translational physiology. Physiology is viewed broadly, having overlapping context with related disciplines such as biomechanics, biochemistry, endocrinology, ergonomics, immunology, motor control, and nutrition. EJAP welcomes studies dealing with physical exercise, training and performance. Studies addressing physiological mechanisms are preferred over descriptive studies. Papers dealing with animal models or pathophysiological conditions are not excluded from consideration, but must be clearly relevant to human physiology.