Funding Strategies to Foster Enabling Basic Science Research in the Development of an HIV Vaccine.

IF 1 4区 医学 Q4 IMMUNOLOGY
Stuart Z Shapiro
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引用次数: 0

Abstract

Despite recent advances in other prevention strategies, an effective vaccine is still needed to guarantee a sustained end to the HIV/AIDS pandemic. However, the traditional ap-proaches of vaccinology have thus far failed to produce an effective vaccine. More basic research may be needed to enhance our understanding of HIV immunity and the immunological principles behind vaccination and to leverage advanced technologies before applied research activities can be successfully used to develop a distributable HIV vaccine. US Government funding plays a crucial role in promoting, enabling, and advising independent scientists and experts to perform such research. This article was written to provide, to the broader scientific community, detail about the tools NIAID uses for research funding, how and why they were used for HIV vaccine development, and how they have been helpful; it is written from the perspective of a Program Officer's experiences while working for more than 25 years in the Division of AIDS (DAIDS) of NIAID at the NIH (the US National Institutes of Health). Several types of funding activities pro-mote HIV vaccine development efforts, but three types of such activities and their impact on HIV vaccine development will be discussed in more detail.

促进在研制艾滋病毒疫苗方面进行有利的基础科学研究的供资战略。
尽管最近在其他预防战略方面取得了进展,但仍然需要一种有效的疫苗来保证持续制止艾滋病毒/艾滋病的流行。然而,传统的疫苗学方法迄今未能生产出有效的疫苗。可能需要进行更多的基础研究,以加强我们对艾滋病毒免疫和疫苗接种背后的免疫学原理的了解,并在应用研究活动成功用于开发可分发的艾滋病毒疫苗之前利用先进技术。美国政府资助在促进、支持和建议独立科学家和专家进行此类研究方面发挥着至关重要的作用。这篇文章是为了向更广泛的科学界提供NIAID用于研究资金的工具的详细信息,它们如何以及为什么被用于艾滋病毒疫苗的开发,以及它们如何起作用;它是从一个项目官员在美国国立卫生研究院(NIH)艾滋病部门(DAIDS)工作超过25年的经历的角度写的。若干类型的筹资活动促进艾滋病毒疫苗开发工作,但将更详细地讨论三种类型的此类活动及其对艾滋病毒疫苗开发的影响。
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来源期刊
Current HIV Research
Current HIV Research 医学-病毒学
CiteScore
1.90
自引率
10.00%
发文量
81
审稿时长
6-12 weeks
期刊介绍: Current HIV Research covers all the latest and outstanding developments of HIV research by publishing original research, review articles and guest edited thematic issues. The novel pioneering work in the basic and clinical fields on all areas of HIV research covers: virus replication and gene expression, HIV assembly, virus-cell interaction, viral pathogenesis, epidemiology and transmission, anti-retroviral therapy and adherence, drug discovery, the latest developments in HIV/AIDS vaccines and animal models, mechanisms and interactions with AIDS related diseases, social and public health issues related to HIV disease, and prevention of viral infection. Periodically, the journal invites guest editors to devote an issue on a particular area of HIV research of great interest that increases our understanding of the virus and its complex interaction with the host.
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