Eosinophils differentially affect early and delayed neurological deterioration after mechanical thrombectomy in stroke.

IF 2.4 4区医学 Q3 NEUROSCIENCES

BMC Neuroscience Pub Date : 2025-06-03 DOI:10.1186/s12868-025-00954-8

Shuhong Yu, Jinping Yang, Xiaoting Han, Jijun Shi, Guodong Xiao, Zhiliang Guo

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引用次数: 0

Abstract

Background: To investigate the effect of eosinophils on early (END) and delayed neurological deterioration (DND) after mechanical thrombectomy (MT) in patients with acute ischemic stroke (AIS).

Methods: A total of 442 consecutive AIS patients experiencing MT between May 2017 and January 2023 were analyzed. END and DND were defined as a rise of ≥ 2 points on the National Institutes of Health Stroke Scale (NIHSS) or a fall of ≥ 1 point on the Glasgow Coma Scale or death from baseline to 24 h and from 24 to 72 h, respectively. Multivariate regression analysis, generalize additive models and mediation analysis were used to assess the effect of eosinophils on END and DND and the underlying mechanisms.

Results: 113 (25.17%) and 47 (10.63%) patients had END and DND, respectively. Eosinophils was independently associated with END after adjusting potential confounders (odds ratio, 0.00; 95% CI, 0.00-0.80; P = 0.0441), which is consistent with the result of eosinophils (dichotomous) as a categorical variable (odds ratio, 0.40; 95% CI, 0.24-0.68; P = 0.0006). In assessing the relationship between eosinophils and DND, the inflection point was found to be 0.02, and eosinophils were independently correlated with DND at less than 0.02 (odds ratio, 0.00, 95% CI: 0.00-0.00, P = 0.0038); however, eosinophils ceased to be independently correlated with DND after exceeding 0.02 (P = 0.3519). Mediation analyses confirmed that eosinophils contribute to END in patients through symptomatic intracranial hemorrhage (indirect effect: -0.463; 95%CI: -0.902-0.19; P < 0.001).

Conclusions: The effects of eosinophils on END and DND are not identical.

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嗜酸性粒细胞对脑卒中机械取栓后早期和延迟性神经退化的影响不同。

背景：探讨嗜酸性粒细胞对急性缺血性卒中（AIS）患者机械取栓（MT）后早期（END）和延迟性神经功能恶化（DND）的影响。方法：对2017年5月至2023年1月期间442例连续接受MT治疗的AIS患者进行分析。END和DND分别定义为美国国立卫生研究院卒中量表（NIHSS）上升≥2分或格拉斯哥昏迷量表下降≥1分或从基线到24小时和从24到72小时死亡。通过多元回归分析、广义加性模型和中介分析，探讨嗜酸性粒细胞对END和DND的影响及其机制。结果：113例（25.17%）发生END， 47例（10.63%）发生DND。调整潜在混杂因素后，嗜酸性粒细胞与END独立相关(优势比，0.00；95% ci, 0.00-0.80；P = 0.0441)，这与嗜酸性粒细胞（二分性）作为分类变量的结果一致(优势比，0.40；95% ci, 0.24-0.68；p = 0.0006)。在评估嗜酸性粒细胞与DND的关系时，发现拐点为0.02，嗜酸性粒细胞与DND的独立相关小于0.02（优势比为0.00,95% CI: 0.00-0.00, P = 0.0038）；然而，嗜酸性粒细胞在超过0.02后不再与DND独立相关（P = 0.3519）。中介分析证实嗜酸性粒细胞通过症状性颅内出血促进患者的END(间接效应：-0.463；95%置信区间:-0.902—-0.19;结论：嗜酸性粒细胞对END和DND的影响并不相同。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Neuroscience 医学-神经科学

CiteScore

3.90

自引率

0.00%

发文量

审稿时长

16 months

期刊介绍： BMC Neuroscience is an open access, peer-reviewed journal that considers articles on all aspects of neuroscience, welcoming studies that provide insight into the molecular, cellular, developmental, genetic and genomic, systems, network, cognitive and behavioral aspects of nervous system function in both health and disease. Both experimental and theoretical studies are within scope, as are studies that describe methodological approaches to monitoring or manipulating nervous system function.