Platelet-Derived Exosome Vulvar Injections for Sexual Dysfunction: A Retrospective Review.

Abstract

Background: PRP derived exosome has been used for a very long time in genital area rejuvenation applications.

Objectives: The aim of this study is to investigate the effect of the newly defined genital PRP derived exosome injection point compared to conventional genital injection points.

Methods: PRP derived exosome was taken into two one cc syringes. 4 injection areas were determined. Only 1 area was injected in each group. In Group A, a total of 2 cc of exosome was injected into the right and left lateral part of the clitoral glans at 3-9 o'clock with a 32 G 4 mm syringe tip. The procedure was applied so that the entire 4 mm syringe tip entered the tissue. In Group B, a total of 2 cc of exosome was injected into the G-spot area around the distal third of the anterior wall with a point-by-point technique with a 32 G 4 mm syringe tip. In group C, exosome injection was performed with a 32 G 4 mm syringe tip, 1 cc on the right side, 1 cc on the left side, and 2 cc in total, to the periurethral area. In group D, exosome injection was performed to the junction point of frenulum, prepuce, and labium minus and its surroundings, 1 cc on the right side, 1 cc on the left side, and 2 cc in total. This procedure was performed in 3 sessions, 4 weeks apart. All patients were evaluated with the FSFI scale before the 1st session and 6 and 12 months after the 3rd session.

Results: The difference between the FSFI increase levels in two different periods for each group was evaluated. Accordingly, the FSFI increase in Group A was similar to the increase in Group D (p=0.715). The FSFI increase in Group B was similar to the increase in Group C (p=0.437). The FSFI increase in Groups A and D was statistically greater than the increase in Groups B and C (Group A vs Group B, p=0.001; Group A vs Group C, p=0.015; Group D vs Group B, p=0.027; Group D vs Group C, p=0.018).

Conclusions: Our study is the first example in the literature in terms of evaluating the difference between the points where PRP-derived exosomes were applied. This new point injection increased FSFI better than group A and was as effective as groups B and C. The effectiveness of this newly defined method has been investigated with a single point injection point, and it is seen that the frequency of application will increase due to its easy applicability, low cost and low side effect rate.