Preparation and Characterization of Diclofenac Sodium-Purolite A430MR Complexes for Taste Masking.

IF 3.4 4区 医学 Q2 PHARMACOLOGY & PHARMACY
Genyang Ye, Qun Wang, Yibo Shang, Yibo Li, Rui Yang, Boyu Jing, Qiang Fu
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引用次数: 0

Abstract

The taste of a drug impacts the compliance of patients for oral administration. In this study, the bitter taste of diclofenac sodium (DS) was masked with purolite A430MR through ion exchange. The DS-A430MR complexes (DACs) were prepared at a 1:1 (w/w) drug to resin through a simple aqueous binding process. The key factors affecting release behaviors were identified by optimized experiments. The taste masking effect of the DACs was evaluated by human taste panel studies and simulated saliva release. The physical characterization proved successful preparation of DACs. The released experiments demonstrated that the pH values, types, and strengths of counter ions were important factors affecting the DS release from the DACs. The simulated saliva release profiles demonstrated that the DS concentration in oral cavity was lower than its bitterness threshold. The bitter taste of DS was almost completely masked by the IERs, which provided guidance for the development of palatable oral preparations using IERs.

双氯芬酸钠- purolite A430MR味掩蔽配合物的制备与表征。
药物的味道会影响患者对口服药物的依从性。在本研究中,双氯芬酸钠(DS)的苦味通过离子交换被purolite A430MR掩盖。通过简单的水结合工艺,以1:1 (w/w)的比例制备了DS-A430MR配合物(dac)。通过优化实验,确定了影响其释放行为的关键因素。通过人类味觉面板研究和模拟唾液释放来评估DACs的味觉掩蔽效应。物理表征证明了DACs的成功制备。释放的实验表明,pH值、反离子类型和强度是影响DACs释放DS的重要因素。模拟唾液释放谱显示,DS在口腔中的浓度低于其苦味阈值。碘化钾的苦味几乎完全被碘化钾所掩盖,这为利用碘化钾开发可口的口服制剂提供了指导。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
AAPS PharmSciTech
AAPS PharmSciTech 医学-药学
CiteScore
6.80
自引率
3.00%
发文量
264
审稿时长
2.4 months
期刊介绍: AAPS PharmSciTech is a peer-reviewed, online-only journal committed to serving those pharmaceutical scientists and engineers interested in the research, development, and evaluation of pharmaceutical dosage forms and delivery systems, including drugs derived from biotechnology and the manufacturing science pertaining to the commercialization of such dosage forms. Because of its electronic nature, AAPS PharmSciTech aspires to utilize evolving electronic technology to enable faster and diverse mechanisms of information delivery to its readership. Submission of uninvited expert reviews and research articles are welcomed.
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