The Effect of Transcranial Direct Stimulation Over Cerebellum and Suplementary Motor Area on Balance Functions in Healthy Young Adults: A Resting EEG-tDCS Study

IF 1.7 4区医学 Q3 DEVELOPMENTAL BIOLOGY

International Journal of Developmental Neuroscience Pub Date : 2025-06-04 DOI:10.1002/jdn.70026

Zeynep Soy, Mevhibe Saricaoglu, Ozden Erkan Ogul, Lutfu Hanoglu, Fatma Karantay Mutluay

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Abstract

This study aims to examine the impact of anodal transcranial direct stimulation (tDCS) targeting the cerebellum (CER) and the supplementary motor area (SMA) on both balance function and resting-state beta activity. A cohort of 28 healthy young individuals participated in the study. Each session involved administering CER, SMA and sham stimulations. Balance assessments were performed before and after stimulation, alongside recording resting-state EEG beta activity. Results revealed a significant increase in the Balance Error Scoring System (BESS) score and certain step distances in the Star Excursion Balance Test (SEBT) following both cerebellar and sham stimulation, as well as in specific step distances of the SEBT following SMA stimulation (p < 0.005). Moreover, there was a noticeable rise in resting-state beta-band power values from pre-tDCS to post-tDCS (p < 0.001). Post hoc comparison analysis indicated a significant enhancement in beta power following cerebellar stimulation (p = 0.034). A correlation appeared between the increase in beta activation after cerebellar stimulation and the SEBT (p < 0.005). The efficacy of cerebellar, SMA and sham stimulation in modulating balance function. It elucidates the modulation of resting-state beta activity through tDCS, particularly highlighting a significant increase in beta activity after cerebellum stimulation, potentially implicating alterations in balance tests consequent to this notable augmentation.

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经颅直接刺激小脑和辅助运动区对健康年轻人平衡功能的影响：静息EEG-tDCS研究

本研究旨在探讨针对小脑（CER）和辅助运动区（SMA）的阳极经颅直接刺激（tDCS）对平衡功能和静息状态β活性的影响。28名健康的年轻人参加了这项研究。每一阶段都包括给予CER、SMA和假刺激。在刺激前后进行平衡评估，同时记录静息状态脑电图β活动。结果显示，在小脑刺激和假脑刺激后，平衡误差评分系统（BESS）得分和星移平衡测试（SEBT）中的某些步距显著增加，以及SMA刺激后SEBT的特定步距显著增加（p < 0.005）。此外，静息状态β波段功率值从tdcs前到tdcs后显著上升（p < 0.001）。事后比较分析显示，小脑刺激后β能量显著增强（p = 0.034）。小脑刺激后β激活的增加与SEBT之间存在相关性（p < 0.005）。小脑、SMA和假刺激对平衡功能的调节作用。它阐明了通过tDCS对静息状态β活性的调节，特别强调了小脑刺激后β活性的显著增加，这可能意味着这种显著增强导致平衡测试的改变。

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来源期刊

International Journal of Developmental Neuroscience 医学-发育生物学

CiteScore

3.30

自引率

5.60%

发文量

审稿时长

6-12 weeks

期刊介绍： International Journal of Developmental Neuroscience publishes original research articles and critical review papers on all fundamental and clinical aspects of nervous system development, renewal and regeneration, as well as on the effects of genetic and environmental perturbations of brain development and homeostasis leading to neurodevelopmental disorders and neurological conditions. Studies describing the involvement of stem cells in nervous system maintenance and disease (including brain tumours), stem cell-based approaches for the investigation of neurodegenerative diseases, roles of neuroinflammation in development and disease, and neuroevolution are also encouraged. Investigations using molecular, cellular, physiological, genetic and epigenetic approaches in model systems ranging from simple invertebrates to human iPSC-based 2D and 3D models are encouraged, as are studies using experimental models that provide behavioural or evolutionary insights. The journal also publishes Special Issues dealing with topics at the cutting edge of research edited by Guest Editors appointed by the Editor in Chief. A major aim of the journal is to facilitate the transfer of fundamental studies of nervous system development, maintenance, and disease to clinical applications. The journal thus intends to disseminate valuable information for both biologists and physicians. International Journal of Developmental Neuroscience is owned and supported by The International Society for Developmental Neuroscience (ISDN), an organization of scientists interested in advancing developmental neuroscience research in the broadest sense.