Comparative analysis of the chick embryo area vasculosa and chorioallantoic membrane as experimental models to study angiogenesis and anti-angiogenesis

IF 2.9 4区医学 Q2 PATHOLOGY

Pathology, research and practice Pub Date : 2025-05-31 DOI:10.1016/j.prp.2025.156067

Domenico Ribatti

引用次数: 0

Abstract

The vascularized extraembryonic membranes of the chick embryo include the area vasculosa (AV) and the chorioallantoic membrane (CAM), both used to study angiogenesis and anti-angiogenesis. In this article we compare these two experimental models and show that AV may be more suitable for the screening of putative angiogenic and anti-angiogenic molecules in alternative to the CAM, more useful to study tumor growth, angiogenesis, and metastasis, and of the angiogenic activity of acellular scaffolds and organoids.

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以鸡胚区血管和绒毛膜尿囊膜为实验模型进行血管生成和抗血管生成的对比分析

鸡胚的血管化胚外膜包括血管区（AV）和绒毛膜-尿囊膜（CAM），它们都用于研究血管生成和抗血管生成。在本文中，我们对这两种实验模型进行了比较，结果表明AV可能比CAM更适合于筛选推定的血管生成和抗血管生成分子，更有助于研究肿瘤的生长、血管生成和转移，以及脱细胞支架和类器官的血管生成活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pathology, research and practice 医学-病理学

CiteScore

5.00

自引率

3.60%

发文量

405

审稿时长

24 days

期刊介绍： Pathology, Research and Practice provides accessible coverage of the most recent developments across the entire field of pathology: Reviews focus on recent progress in pathology, while Comments look at interesting current problems and at hypotheses for future developments in pathology. Original Papers present novel findings on all aspects of general, anatomic and molecular pathology. Rapid Communications inform readers on preliminary findings that may be relevant for further studies and need to be communicated quickly. Teaching Cases look at new aspects or special diagnostic problems of diseases and at case reports relevant for the pathologist''s practice.