Interaction of obesity and systemic inflammation with knee extensor strength in knee osteoarthritis

IF 1.4 3区医学 Q4 ENGINEERING, BIOMEDICAL

Clinical Biomechanics Pub Date : 2025-05-31 DOI:10.1016/j.clinbiomech.2025.106569

L. Straatman , N.K. Ivanochko , J.M. Maciukiewicz , B. Cowbrough , K.A. Marriott , D.E. Bowdish , E. Wiebenga , K.F. Webster , P. Stratford , M.R. Maly

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引用次数: 0

Abstract

Background

Knee osteoarthritis is accompanied by reduced muscle strength and a greater body mass index (BMI). Large BMI from accumulated fat mass is linked with greater systemic inflammation. Separate studies show inflammation is associated with reduced muscle strength in healthy adults. The purpose of this study was to investigate whether systemic inflammatory biomarkers interact with BMI to relate with knee extensor strength, and if the relationship differs based on sex.

Methods

93 participants with clinical knee osteoarthritis (n = 59 females, n = 34 males) were included. Knee extensor strength (Nm) was an average of 5 maximum voluntary isometric knee extension efforts. BMI was measured while barefoot, wearing a t-shirt and shorts. Serum cytokines were obtained from venous blood samples from the antecubital fossae following a 30-min rest period. Linear regressions tested the interaction effect of each CRP and IL-10 on the relationship between knee extensor strength (dependent variable) and BMI (independent variable), for both males and females.

Findings

Among females with a large BMI, higher levels of IL-10 related to greater knee extensor strength (t = 2.18, p = 0.03). For males, the interaction of IL-10 (t = 0.61, p = 0.55) with CRP (t = −1.75, p = 0.09) with BMI was not significant.

Interpretation:

Anti-inflammatory properties of IL-10 may serve to balance the effect of an increased BMI in females by counteracting inflammation-induced muscle damage. Understanding this association provides insight into biological factors that may contribute to disease progression, serving as a potential target for therapeutic interventions.

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膝关节骨关节炎中肥胖和全身性炎症与膝关节伸肌力量的相互作用

膝关节骨性关节炎伴随着肌肉力量下降和身体质量指数（BMI）升高。脂肪堆积导致的身体质量指数过高与更严重的全身性炎症有关。单独的研究表明，炎症与健康成年人的肌肉力量下降有关。本研究的目的是调查全身性炎症生物标志物是否与BMI相互作用，与膝关节伸肌力量有关，以及这种关系是否因性别而异。方法纳入临床膝关节骨性关节炎患者93例（女性59例，男性34例）。膝关节伸肌强度（Nm）平均为5次最大自主等距膝关节伸肌。BMI是在赤脚、穿着t恤和短裤的情况下测量的。静息30分钟后，从枕前窝静脉血中提取血清细胞因子。线性回归测试了每种CRP和IL-10对男性和女性膝关节伸肌力量（因变量）和BMI（自变量）之间关系的相互作用。在BMI较大的女性中，较高水平的IL-10与较大的膝关节伸肌力量相关（t = 2.18, p = 0.03）。对于男性，IL-10 （t = 0.61, p = 0.55）与CRP （t = - 1.75, p = 0.09）与BMI的相互作用不显著。解释：IL-10的抗炎特性可能通过抵消炎症引起的肌肉损伤来平衡女性BMI增加的影响。了解这种关联有助于深入了解可能导致疾病进展的生物学因素，作为治疗干预的潜在目标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Biomechanics 医学-工程：生物医学

CiteScore

3.30

自引率

5.60%

发文量

189

审稿时长

12.3 weeks

期刊介绍： Clinical Biomechanics is an international multidisciplinary journal of biomechanics with a focus on medical and clinical applications of new knowledge in the field. The science of biomechanics helps explain the causes of cell, tissue, organ and body system disorders, and supports clinicians in the diagnosis, prognosis and evaluation of treatment methods and technologies. Clinical Biomechanics aims to strengthen the links between laboratory and clinic by publishing cutting-edge biomechanics research which helps to explain the causes of injury and disease, and which provides evidence contributing to improved clinical management. A rigorous peer review system is employed and every attempt is made to process and publish top-quality papers promptly. Clinical Biomechanics explores all facets of body system, organ, tissue and cell biomechanics, with an emphasis on medical and clinical applications of the basic science aspects. The role of basic science is therefore recognized in a medical or clinical context. The readership of the journal closely reflects its multi-disciplinary contents, being a balance of scientists, engineers and clinicians. The contents are in the form of research papers, brief reports, review papers and correspondence, whilst special interest issues and supplements are published from time to time. Disciplines covered include biomechanics and mechanobiology at all scales, bioengineering and use of tissue engineering and biomaterials for clinical applications, biophysics, as well as biomechanical aspects of medical robotics, ergonomics, physical and occupational therapeutics and rehabilitation.