{"title":"Novel muscle injury treatment in rats","authors":"Jorge Ferreira","doi":"10.1038/s41684-025-01563-y","DOIUrl":null,"url":null,"abstract":"<p>Muscle injuries are common in sports and daily life, involving inflammation, regeneration and remodeling of muscle tissue. A study in <i>Scientific Reports</i> evaluated the effects of two subtypes of platelet-rich plasma (PRP), the leukocyte-poor PRP (LP-PRP) and the leukocyte-rich PRP (LR-PRP), and the peptide antagonist of the domains 1 and 2 of the IL-1β receptor (DAP1-2) on inflammation following muscle contusion in Wistar rats. Treatment with LP-PRP and DAP1-2, individually or combined, showed the most significant effects. Notably, RT-qPCR and ELISA showed a modulation of early inflammation markers compared to the control injury group and that the treatment promotes an efficient transition from the initial inflammation stage to tissue regeneration. However, the study endpoint was five days post-injury, limiting insights into long-term effects. The combined use of LP-PRP and IL-1β inhibitor peptides may represent a novel therapeutic strategy for acute muscle injuries, but further research is needed to confirm efficacy and understand mechanisms of action.</p><p><b>Original reference:</b> Colares, M.C. et al. <i>Sci. Rep</i>. <b>15</b>, 14219 (2025)</p>","PeriodicalId":17936,"journal":{"name":"Lab Animal","volume":"8 1","pages":""},"PeriodicalIF":5.9000,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Lab Animal","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.1038/s41684-025-01563-y","RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"VETERINARY SCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
Muscle injuries are common in sports and daily life, involving inflammation, regeneration and remodeling of muscle tissue. A study in Scientific Reports evaluated the effects of two subtypes of platelet-rich plasma (PRP), the leukocyte-poor PRP (LP-PRP) and the leukocyte-rich PRP (LR-PRP), and the peptide antagonist of the domains 1 and 2 of the IL-1β receptor (DAP1-2) on inflammation following muscle contusion in Wistar rats. Treatment with LP-PRP and DAP1-2, individually or combined, showed the most significant effects. Notably, RT-qPCR and ELISA showed a modulation of early inflammation markers compared to the control injury group and that the treatment promotes an efficient transition from the initial inflammation stage to tissue regeneration. However, the study endpoint was five days post-injury, limiting insights into long-term effects. The combined use of LP-PRP and IL-1β inhibitor peptides may represent a novel therapeutic strategy for acute muscle injuries, but further research is needed to confirm efficacy and understand mechanisms of action.
Original reference: Colares, M.C. et al. Sci. Rep. 15, 14219 (2025)
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LabAnimal is a Nature Research journal dedicated to in vivo science and technology that improves our basic understanding and use of model organisms of human health and disease. In addition to basic research, methods and technologies, LabAnimal also covers important news, business and regulatory matters that impact the development and application of model organisms for preclinical research.
LabAnimal's focus is on innovative in vivo methods, research and technology covering a wide range of model organisms. Our broad scope ensures that the work we publish reaches the widest possible audience. LabAnimal provides a rigorous and fair peer review of manuscripts, high standards for copyediting and production, and efficient publication.
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