Hippocampal microglia’s role in neuropathic pain

IF 5.9 3区农林科学 Q1 VETERINARY SCIENCES

Lab Animal Pub Date : 2025-06-03 DOI:10.1038/s41684-025-01562-z

Jorge Ferreira

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Abstract

Neuropathic pain often occurs alongside cognitive impairment, but the mechanisms behind this relationship remain unclear. A study in Behavioral Brain Research investigates the microglial activation in brain regions involved in emotion, memory and pain processing in male mice of a partial sciatic nerve ligation (PSNL) model. Two weeks post-injury, Iba1 and P2RY12 immunoreactivity—two markers of microglial activation—were significantly increased in the hippocampus and amygdala, but not the perirhinal cortex. Targeted microinjection of clodronate liposomes, depleting microglia, into the hippocampus, but not the amygdala, alleviated both mechanical allodynia and cognitive deficits. Hippocampal clodronate treatment also prevented the PSNL-induced degenerative changes in neuronal morphology. These results show that hippocampal microglial activation has an important role in both pain sensitivity and cognitive dysfunction following nerve injury. The results support that region-specific microglial activation contributes to neuropathic pain and show that the hippocampus can be a potential therapeutic target.

Original reference: Hisaoka-Nakashima, K. et al. Behav. Brain Res. 488, 115590 (2025)

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海马小胶质细胞在神经性疼痛中的作用

神经性疼痛通常与认知障碍同时发生，但这种关系背后的机制尚不清楚。《行为脑研究》对部分坐骨神经结扎（PSNL）雄性小鼠的情绪、记忆和疼痛处理区域的小胶质细胞激活进行了研究。损伤后两周，海马和杏仁核中Iba1和P2RY12免疫反应性（两种小胶质细胞激活的标志物）显著增加，但在鼻周皮层中没有。将消耗小胶质细胞的氯膦酸脂质体靶向注射到海马体，而不是杏仁核，减轻了机械异常性疼痛和认知缺陷。海马氯膦酸钠治疗也能阻止psnl诱导的神经元形态退行性改变。这些结果表明，海马小胶质细胞的激活在神经损伤后的疼痛敏感性和认知功能障碍中都起重要作用。结果支持区域特异性小胶质细胞激活有助于神经性疼痛，并表明海马体可能是一个潜在的治疗靶点。原始参考文献：Hisaoka-Nakashima， K.等。Behav。脑科学，488,115590 （2025）

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来源期刊

Lab Animal 农林科学-兽医学

CiteScore

0.60

自引率

2.90%

发文量

181

审稿时长

>36 weeks

期刊介绍： LabAnimal is a Nature Research journal dedicated to in vivo science and technology that improves our basic understanding and use of model organisms of human health and disease. In addition to basic research, methods and technologies, LabAnimal also covers important news, business and regulatory matters that impact the development and application of model organisms for preclinical research. LabAnimal's focus is on innovative in vivo methods, research and technology covering a wide range of model organisms. Our broad scope ensures that the work we publish reaches the widest possible audience. LabAnimal provides a rigorous and fair peer review of manuscripts, high standards for copyediting and production, and efficient publication.