Fecal microbiota transplantation therapy

IF 5.9 3区农林科学 Q1 VETERINARY SCIENCES

Lab Animal Pub Date : 2025-06-03 DOI:10.1038/s41684-025-01564-x

Jorge Ferreira

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Abstract

The gut microbiota influences both gastrointestinal and neurobehavioral health. A study in Scientific Reports investigated fecal microbiota transplantation (FMT) as a treatment for acetic acid-induced colitis and associated anxiety-like behaviors in rats. Colitis was induced via rectal acetic acid administration, leading to macroscopic colon damage, increased disease index, and elevated expression of NF-κB, NLRP3, Caspase1, IL-1β and IL-18, markers of inflammation, in colon and hippocampal tissues compared to untreated animals. FMT treatment significantly reduced acetic acid-induced colon pathology and suppressed the activation of the NLRP3-Caspase1 signaling pathway. Behavioral tests indicated that FMT also alleviated anxiety-like symptoms. Mechanistically, FMT downregulated NF-κB, NLRP3, and Caspase1 expression and decreased IL-1β and IL-18 levels in both the colon and hippocampus. These findings suggest that FMT exerts anti-inflammatory and anxiolytic effects through modulation of the NLRP3 inflammasome. FMT may serve as a therapeutic strategy for treating inflammatory bowel diseases and their associated neurobehavioral comorbidities.

Original reference: Mohammadi, M. et al. Sci. Rep. 15, 14831 (2025)

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粪便微生物群移植治疗

肠道菌群影响胃肠道和神经行为健康。《科学报告》上的一项研究调查了粪便微生物群移植（FMT）作为大鼠醋酸性结肠炎和相关焦虑样行为的治疗方法。经直肠醋酸给药诱导结肠炎，与未给药动物相比，大鼠结肠和海马组织中炎症标志物NF-κB、NLRP3、Caspase1、IL-1β和IL-18表达升高，疾病指数升高。FMT处理显著降低醋酸诱导的结肠病理，抑制NLRP3-Caspase1信号通路的激活。行为测试表明，FMT也减轻了焦虑样症状。机制上，FMT下调了结肠和海马组织中NF-κB、NLRP3和Caspase1的表达，降低了IL-1β和IL-18的水平。这些发现表明FMT通过调节NLRP3炎性体发挥抗炎和抗焦虑作用。FMT可以作为治疗炎症性肠病及其相关神经行为合并症的治疗策略。原始参考文献：Mohammadi， M.等。科学。众议员15,14831 （2025）

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来源期刊

Lab Animal 农林科学-兽医学

CiteScore

0.60

自引率

2.90%

发文量

181

审稿时长

>36 weeks

期刊介绍： LabAnimal is a Nature Research journal dedicated to in vivo science and technology that improves our basic understanding and use of model organisms of human health and disease. In addition to basic research, methods and technologies, LabAnimal also covers important news, business and regulatory matters that impact the development and application of model organisms for preclinical research. LabAnimal's focus is on innovative in vivo methods, research and technology covering a wide range of model organisms. Our broad scope ensures that the work we publish reaches the widest possible audience. LabAnimal provides a rigorous and fair peer review of manuscripts, high standards for copyediting and production, and efficient publication.