Jacques Behmoaras, Kevin Mulder, Florent Ginhoux, Enrico Petretto
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引用次数: 0
Abstract
Macrophages are active participants of tissue repair and when normal repair processes fail, fibrosis can ensue, which leads to major organ dysfunction and affects nearly a billion people worldwide. Here we focus on macrophages in the spatiotemporal control of fibrosis, drawing on our understanding of the roles of these cells in organogenesis, adult organ homeostasis and wound repair. We describe recent insights from single-cell transcriptomics studies of human and mouse tissues that reveal macrophage heterogeneity in healthy and fibrotic niches, as well as the pathways underlying macrophage–fibroblast cooperation during progression from inflammation to fibrosis. Finally, we propose a model to explain how macrophage activity over time and across different tissues controls tissue fibrosis, we discuss therapeutic initiatives based on regulation of macrophage activity and we recommend future research directions.
期刊介绍：
Nature Reviews Immunology is a journal that provides comprehensive coverage of all areas of immunology, including fundamental mechanisms and applied aspects. It has two international standard serial numbers (ISSN): 1474-1733 for print and 1474-1741 for online. In addition to review articles, the journal also features recent developments and new primary papers in the field, as well as reflections on influential people, papers, and events in the development of immunology. The subjects covered by Nature Reviews Immunology include allergy and asthma, autoimmunity, antigen processing and presentation, apoptosis and cell death, chemokines and chemokine receptors, cytokines and cytokine receptors, development and function of cells of the immune system, haematopoiesis, infection and immunity, immunotherapy, innate immunity, mucosal immunology and the microbiota, regulation of the immune response, signalling in the immune system, transplantation, tumour immunology and immunotherapy, and vaccine development.
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