Persistence of SARS-CoV-2 Alpha Variant in White-Tailed Deer, Ohio, USA

IF 7.2 2区医学 Q1 IMMUNOLOGY

Emerging Infectious Diseases Pub Date : 2025-06-03 DOI:10.3201/eid3107.241922

Natalie N. Tarbuck, Sofya K. Garushyants, Dillon S. McBride, Patricia M. Dennis, John Franks, Karlie Woodard, Austin Shamblin, Michael G. Sovic, Derek T. Collins, Kyle Van Why, Richard J. Webby, Martha I. Nelson, Andrew S. Bowman

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引用次数: 0

Abstract

Free-ranging white-tailed deer (WTD) are highly susceptible to the SARS-CoV-2 virus. Through an opportunistic sampling of WTD in northeast Ohio, USA, during January–March 2023, we identified 6 SARS-CoV-2 lineages from 36 sequences using the pangolin lineages tool, including the B.1.1.7 lineage (Alpha variant) and BQ.1.1, BQ.1.1.63, BQ.1.1.67, BQ.1.23, and XBB.1.5.35 lineages (Omicron variant). The Alpha variant, introduced by a single human-to-deer transmission event, was detected in 5 WTD in January 2023, more than 1 year after the most recent detection of the Alpha variant in humans in Ohio (August 2021). A genetically similar B.1.1.7 lineage virus from WTD in a nearby county in Pennsylvania was positioned with our Ohio deer transmission cluster, suggesting deer-to-deer transmission. The persistence of the Alpha variant in WTD in Ohio warrants continued surveillance to monitor if WTD can become a reservoir for displaced SARS-CoV-2 variants.

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美国俄亥俄州白尾鹿中SARS-CoV-2 α变异的持久性

自由放养的白尾鹿对SARS-CoV-2病毒高度敏感。通过对2023年1 - 3月美国俄亥俄州东北部WTD的机会性采样，我们使用穿山甲谱系工具从36个序列中鉴定出6个SARS-CoV-2谱系，包括B.1.1.7谱系（Alpha变体）和BQ.1.1、BQ.1.1.63、BQ.1.1.67、BQ.1.23和XBB.1.5.35谱系（Omicron变体）。在俄亥俄州（2021年8月）最近发现人类α变异一年多之后，于2023年1月在5个WTD中发现了由单个人-鹿传播事件引入的α变异。来自宾夕法尼亚州附近县的WTD遗传相似的B.1.1.7谱系病毒与我们的俄亥俄州鹿传播聚集群定位在一起，表明鹿对鹿的传播。俄亥俄州WTD中α变体的持续存在值得继续监测，以监测WTD是否可以成为转移的SARS-CoV-2变体的储存库。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Emerging Infectious Diseases 医学-传染病学

CiteScore

17.30

自引率

1.70%

发文量

505

审稿时长

1 months

期刊介绍： Emerging Infectious Diseases is a monthly open access journal published by the Centers for Disease Control and Prevention. The primary goal of this peer-reviewed journal is to advance the global recognition of both new and reemerging infectious diseases, while also enhancing our understanding of the underlying factors that contribute to disease emergence, prevention, and elimination. Targeted towards professionals in the field of infectious diseases and related sciences, the journal encourages diverse contributions from experts in academic research, industry, clinical practice, public health, as well as specialists in economics, social sciences, and other relevant disciplines. By fostering a collaborative approach, Emerging Infectious Diseases aims to facilitate interdisciplinary dialogue and address the multifaceted challenges posed by infectious diseases.