Molecular Perspectives on Meningioma with Osseous Infiltration Revealed by ⁶⁸Ga-DOTA TOC PET-CT.

IF 1.1 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Molecular Imaging and Radionuclide Therapy Pub Date : 2025-06-03 DOI:10.4274/mirt.galenos.2024.99267

Sharjeel Usmani, Anjali Jain, Khulood Al Riyami, Syed Furqan Hashmi, Jamsari Khalid, Subhash Kheruka

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引用次数: 0

Abstract

Meningiomas express the somatostatin receptor (SSTR). The utilization of SSTR ligands, specifically Gallium-68 (⁶⁸Ga) isotope, a radioactive isotope (⁶⁸Ga)-DOTA-labeled peptides, has demonstrated exceptional diagnostic precision for the detection of meningiomas, primarily due to the absence of normal brain and bone activity. We report a case of a 48-year-old woman with sphenoid wing meningioma who underwent ⁶⁸Ga-DOTA TOC positron emission tomography (PET) for tumor delineation. ⁶⁸Ga-DOTA TOC PET shows SSTR-avid meningioma in the right sphenoid/anterior temporal region with significant hyperostosis with high expression of SSTR in the bone. ⁶⁸Ga-DOTA TOC uptake in the hyperostosis signifies bone infiltration rather than reactive changes. ⁶⁸Ga-DOTA PET provides a better assessment of osseous involvement and provides additional information in terms of meningioma extent and planning for further management.

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68Ga-DOTA TOC PET-CT显示脑膜瘤伴骨浸润的分子研究进展。

脑膜瘤表达生长抑素受体（SSTR）。利用SSTR配体，特别是镓-68 （68Ga）同位素，一种放射性同位素(68Ga)- dota标记的肽，在脑膜瘤的检测中表现出卓越的诊断精度，主要是由于缺乏正常的脑和骨活动。我们报告一例48岁女性蝶翼脑膜瘤，她接受了68Ga-DOTA TOC正电子发射断层扫描（PET）来描绘肿瘤。68Ga-DOTA TOC PET显示右侧蝶骨/颞前区SSTR阳性脑膜瘤，骨内SSTR高表达，骨质增生明显。骨质增生的68Ga-DOTA TOC摄取表明骨浸润而非反应性改变。68Ga-DOTA PET可以更好地评估骨受累情况，并提供关于脑膜瘤范围和进一步治疗计划的额外信息。

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来源期刊

Molecular Imaging and Radionuclide Therapy RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-

CiteScore

1.30

自引率

0.00%

发文量

期刊介绍： Molecular Imaging and Radionuclide Therapy (Mol Imaging Radionucl Ther, MIRT) is publishes original research articles, invited reviews, editorials, short communications, letters, consensus statements, guidelines and case reports with a literature review on the topic, in the field of molecular imaging, multimodality imaging, nuclear medicine, radionuclide therapy, radiopharmacy, medical physics, dosimetry and radiobiology.