Ujjawal Roy, Ajay Panwar, Michael S Cartwright, A K Srivastava, Bhashwati Mukherjee, Harshita Vaibhaw, Shashi Bhushan Singh, Rahul Sharma, Neha Rani, Itu Singh, Chittaranjan Roy
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引用次数: 0
Abstract
Objectives: We aimed to compare the clinical, electrophysiologic, and sonographic characteristics of commonly affected peripheral nerves in suspected cases of pure neuritic leprosy (PNL) and to describe an ultrasound-guided fine needle aspiration cytology (FNAC) procedure to improve diagnostic capabilities in PNL.
Methods: This retrospective study was carried out at Roy Neuro Care Centre, Ranchi, Jharkhand, India through revisiting charts of suspected cases of PNL from October 2022 to June 2024. The charts of individuals with a history, examination, and nerve ultrasound consistent with PNL were reviewed. We retrospectively analyzed the diagnostic steps, including the skin biopsy (which had been guided by electrophysiology and/or nerve ultrasound) and the ultrasound-guided FNAC of nerves that had been sent for histopathological examination, acid-fast bacilli (AFB) staining, and polymerase chain reaction (PCR).
Results: Charts of 52 patients derived from the records of those with mononeuropathy or mononeuritis multiplex suspected to have PNL during October 2022-June 2024 were evaluated. The skin biopsy was diagnostic of PNL in 23 patients, while 29 patients had an inconclusive result. Those with an inconclusive result had an ultrasound-guided FNAC followed by cytology and AFB staining. The review of the records of these cases revealed that in 24 (82.8%) cases there were features suggestive of PNL, while 5 patients had negative cytology and AFB staining. Three of these individuals had PCR, with a positive result in 1 (33.3%). A positive correlation was noted between the duration of illness and markers of progressive involvement of nerves, as determined by electrodiagnosis and ultrasound.
Conclusion: Nerve ultrasound and ultrasound-guided nerve FNAC can assist in the early diagnosis of PNL.
期刊介绍：
The Journal of Clinical Ultrasound (JCU) is an international journal dedicated to the worldwide dissemination of scientific information on diagnostic and therapeutic applications of medical sonography.
The scope of the journal includes--but is not limited to--the following areas: sonography of the gastrointestinal tract, genitourinary tract, vascular system, nervous system, head and neck, chest, breast, musculoskeletal system, and other superficial structures; Doppler applications; obstetric and pediatric applications; and interventional sonography. Studies comparing sonography with other imaging modalities are encouraged, as are studies evaluating the economic impact of sonography. Also within the journal''s scope are innovations and improvements in instrumentation and examination techniques and the use of contrast agents.
JCU publishes original research articles, case reports, pictorial essays, technical notes, and letters to the editor. The journal is also dedicated to being an educational resource for its readers, through the publication of review articles and various scientific contributions from members of the editorial board and other world-renowned experts in sonography.
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