Seroprevalence of Hepatitis A in Non-vaccinated Adolescents Aged 9 to 12 Years in New Delhi, India: A Cross-Sectional Study.

IF 1.7 4区医学 Q2 PEDIATRICS

Indian pediatrics Pub Date : 2025-06-03 DOI:10.1007/s13312-025-00090-w

Anurag Agarwal, Shweta Sajlan, Rohit Chawla, Surendra Bahadur Mathur

{"title":"Seroprevalence of Hepatitis A in Non-vaccinated Adolescents Aged 9 to 12 Years in New Delhi, India: A Cross-Sectional Study.","authors":"Anurag Agarwal, Shweta Sajlan, Rohit Chawla, Surendra Bahadur Mathur","doi":"10.1007/s13312-025-00090-w","DOIUrl":null,"url":null,"abstract":"Objective: To determine the seroprevalence of hepatitis A among non-vaccinated adolescents aged 9-12 years and to ascertain the sociodemographic factors associated with seropositivity.Methods: A cross-sectional study was conducted among non-vaccinated adolescents aged 9-12 years from urban and semi-urban settings in New Delhi. Sera were analyzed using competitive ELISA to detect IgG antibodies against hepatitis A. Sociodemographic data were collected using a structured pro forma.Results: Of the 94 participants, 85 (90.4%) were seropositive for hepatitis A. Seropositivity was significantly associated with low socioeconomic status, lower parental education levels, lower parental occupation status, and low monthly household income.Conclusions: Despite improved sanitation, lower socioeconomic groups remain highly endemic for hepatitis A. Catch-up vaccination may have limited utility in adolescents aged 10 years or older from these backgrounds. Targeted public health strategies and further evaluation of vaccination policies in specific populations are needed.Trial registration: Clinical Trials Registry-India No. CTRI/2022/10/046790.Obtained.","PeriodicalId":13291,"journal":{"name":"Indian pediatrics","volume":" ","pages":""},"PeriodicalIF":1.7000,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Indian pediatrics","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s13312-025-00090-w","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PEDIATRICS","Score":null,"Total":0}

引用次数: 0

Abstract

Objective: To determine the seroprevalence of hepatitis A among non-vaccinated adolescents aged 9-12 years and to ascertain the sociodemographic factors associated with seropositivity.

Methods: A cross-sectional study was conducted among non-vaccinated adolescents aged 9-12 years from urban and semi-urban settings in New Delhi. Sera were analyzed using competitive ELISA to detect IgG antibodies against hepatitis A. Sociodemographic data were collected using a structured pro forma.

Results: Of the 94 participants, 85 (90.4%) were seropositive for hepatitis A. Seropositivity was significantly associated with low socioeconomic status, lower parental education levels, lower parental occupation status, and low monthly household income.

Conclusions: Despite improved sanitation, lower socioeconomic groups remain highly endemic for hepatitis A. Catch-up vaccination may have limited utility in adolescents aged 10 years or older from these backgrounds. Targeted public health strategies and further evaluation of vaccination policies in specific populations are needed.

Trial registration: Clinical Trials Registry-India No. CTRI/2022/10/046790.Obtained.

查看原文本刊更多论文

印度新德里未接种甲型肝炎疫苗的9至12岁青少年血清患病率：一项横断面研究。

目的：了解未接种甲型肝炎疫苗的9-12岁青少年的血清阳性率，并确定与血清阳性相关的社会人口因素。方法：在新德里城市和半城市地区未接种疫苗的9-12岁青少年中进行了一项横断面研究。采用竞争性ELISA法分析血清，检测抗甲型肝炎IgG抗体。采用结构化表格收集社会人口统计数据。结果：94名参与者中，85名（90.4%）甲型肝炎血清阳性。血清阳性与低社会经济地位、低父母教育水平、低父母职业状况和低家庭月收入显著相关。结论：尽管卫生条件有所改善，但社会经济地位较低的群体仍然是甲型肝炎的高度流行人群，补种疫苗对这些背景的10岁或以上青少年的效用可能有限。有必要制定有针对性的公共卫生战略，并进一步评估特定人群的疫苗接种政策。试验注册：Clinical Trials Registry-India No.；CTRI / 2022/10/046790.Obtained。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Indian pediatrics 医学-小儿科

CiteScore

3.30

自引率

8.70%

发文量

344

审稿时长

3-8 weeks

期刊介绍： The general objective of Indian Pediatrics is "To promote the science and practice of Pediatrics." An important guiding principle has been the simultaneous need to inform, educate and entertain the target audience. The specific key objectives are: -To publish original, relevant, well researched peer reviewed articles on issues related to child health. -To provide continuing education to support informed clinical decisions and research. -To foster responsible and balanced debate on controversial issues that affect child health, including non-clinical areas such as medical education, ethics, law, environment and economics. -To achieve the highest level of ethical medical journalism and to produce a publication that is timely, credible and enjoyable to read.