Fatemeh Abbaszadeh, Sajad Fakhri, Behrang Shiri Varnamkhasti, Seyed Zachariah Moradi, Mohammad Hosein Olfati, Zanyar Moradi, Mohammad Reza Khirehgesh, Haroon Khan
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引用次数: 0
Abstract
Introduction: Neurodegenerative diseases (NDDs) refer to a progressive degeneration of the nervous system and are on the rise. Researchers are trying to reveal the crucial mechanisms behind NDDs to find novel therapeutic candidates with higher efficacy and lower side effects. Increasing evidence highlights the auspicious role of inflammatory mechanisms in the pathogenesis of NDDs.
Methods: Based on the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guideline, a systematic and comprehensive review was done to evaluate the effect of medicinal herbs in restoring gut-brain function and anti-inflammatory mechanisms in combating neuroprotection. The electronic databases, including Scopus, PubMed, and ScienceDirect, were searched for the literature review. The manual search of reference lists and citations was also employed falling within the authors' expertise.
Results: As with other mechanisms, the bidirectional communication between the brain and gut, known as the gut-brain axis, has emerged as a potential target for therapeutic interventions. Since the gut-brain axis covers multiple mechanisms, especially inflammatory mechanisms in NDDs, it urges the need for finding novel multi-targeting agents. Medicinal herbs, with their rich repertoire of natural products, are multi-targeting candidates in combating several diseases. In this systematic and comprehensive review, we explore the potential of medicinal herbs in restoring gut-brain function and promoting neuroprotection by suppressing inflammatory pathways. Novel delivery systems and clinical applications of medicinal herbs are also highlighted to drawback the pharmacokinetic limitation in regulating the gut-brain axis-associated NDDs.
Conclusion: Medicinal herbs provide neuroprotective responses through the modulation of gut-brain function and related inflammatory mediators.
神经退行性疾病（ndd）是指神经系统的进行性退行性疾病，发病率呈上升趋势。研究人员正试图揭示ndd背后的关键机制，以寻找具有更高疗效和更低副作用的新型治疗候选药物。越来越多的证据强调炎症机制在ndd发病机制中的有利作用。方法：根据PRISMA （Preferred Reporting Items for Systematic Reviews and Meta-Analysis）指南，对中药恢复肠脑功能的作用及抗炎机制进行系统、全面的评价。检索电子数据库，包括Scopus、PubMed和ScienceDirect。参考书目和引文的手工检索也属于作者的专门知识范围。结果：与其他机制一样，大脑和肠道之间的双向交流，即肠-脑轴，已成为治疗干预的潜在目标。由于肠脑轴涵盖多种机制，特别是ndd中的炎症机制，因此迫切需要寻找新的多靶点药物。草药具有丰富的天然产物，是对抗多种疾病的多靶点候选药物。在这篇系统全面的综述中，我们探讨了草药通过抑制炎症途径恢复肠脑功能和促进神经保护的潜力。新的给药系统和草药的临床应用也强调了在调节肠-脑轴相关ndd方面的药代动力学限制。结论：中药通过调节肠脑功能及相关炎症介质发挥神经保护作用。
期刊介绍：
Current Neuropharmacology aims to provide current, comprehensive/mini reviews and guest edited issues of all areas of neuropharmacology and related matters of neuroscience. The reviews cover the fields of molecular, cellular, and systems/behavioural aspects of neuropharmacology and neuroscience.
The journal serves as a comprehensive, multidisciplinary expert forum for neuropharmacologists and neuroscientists.
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