IgA nephropathy: Update on pathogenesis and treatment.

IF 3.4 4区医学 Q1 MEDICINE, GENERAL & INTERNAL

Cleveland Clinic Journal of Medicine Pub Date : 2025-06-02 DOI:10.3949/ccjm.92a.24105

Seshma Ramsawak, Scott Cohen, Andrea Linares, Corey Cavanaugh

引用次数: 0

Abstract

The pathogenesis of immunoglobulin (Ig) A nephropathy is described through a "4-hit" model involving production of galactose-deficient IgA, production of autoantibodies to galactose-deficient IgA, and subsequent deposition of immune complexes in the kidney glomerulus. Diagnosis remains dependent on a kidney biopsy, often after hematuria or proteinuria is detected on urinalysis. The cornerstone of therapy still involves renin-angiotensin-aldosterone system inhibitors or corticosteroids; however, new therapies targeting key aspects of the pathogenesis of IgA nephropathy are being introduced.

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IgA肾病：发病机制和治疗的最新进展

免疫球蛋白（Ig） A肾病的发病机制是通过“4-hit”模型来描述的，该模型涉及产生半乳糖缺乏的IgA，产生针对半乳糖缺乏的IgA的自身抗体，随后在肾小球中沉积免疫复合物。诊断仍然依赖于肾活检，通常在尿液分析中检测到血尿或蛋白尿后。治疗的基础仍然包括肾素-血管紧张素-醛固酮系统抑制剂或皮质类固醇；然而，针对IgA肾病发病机制关键方面的新疗法正在被引入。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cleveland Clinic Journal of Medicine 医学-医学：内科

CiteScore

3.80

自引率

0.00%

发文量

109

审稿时长

6-12 weeks

期刊介绍： The mission of Cleveland Clinic Journal of Medicine (CCJM) is to provide its readers with up-to-date, practical, clinical information relevant to internal medicine, cardiology, and related fields. Consistent with this mission, CCJM focuses on timely review articles and other content that has a continuing-education orientation rather than on original research or case reports. CCJM authors, drawn from Cleveland Clinic and other top medical institutions throughout the world, are asked to identify new findings that are changing the practice of medicine and to advise readers how to apply them in daily patient care. Authors are chosen for their experience, acquired through caring for patients, teaching other physicians, and researching clinical questions.