V E Balakin, N S Strelnikova, O M Rozanova, E N Smirnova, T A Belyakova, A E Shemyakov
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引用次数: 0
Abstract
The regularities of tumor induction and growth were studied in mice after a single ex vivo irradiation with a helium ion beam of Ehrlich adenocarcinoma ascites cells (EAC) at doses of 10 and 20 Gy in two positions of the Bragg curve (before the peak and at the peak) in comparison with X-ray radiation at the same doses. It was shown that the frequency of induction and delay in tumor appearance depend on the dose of helium ion irradiation. The following parameters were determined: the time of a fivefold increase in the EAC volume, tumor growth inhibition, tumor growth index (TGI), and lifetime increase (LTI) in mice. A decrease in the TGI values and an increase in the LTI values occurred with increasing dose for all types of radiation. The relative biological effectiveness (RBE) value for helium ions determined by the area under the EAC growth dynamics curves reached a maximum value of 1.8 upon irradiation at the Bragg peak at a dose of 20 Gy.
期刊介绍：
Doklady Biochemistry and Biophysics is a journal consisting of English translations of articles published in Russian in biochemistry and biophysics sections of the Russian-language journal Doklady Akademii Nauk. The journal''s goal is to publish the most significant new research in biochemistry and biophysics carried out in Russia today or in collaboration with Russian authors. The journal accepts only articles in the Russian language that are submitted or recommended by acting Russian or foreign members of the Russian Academy of Sciences. The journal does not accept direct submissions in English.
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