Ying Han, Li Huang, Jiaojiao Wu, Guiling Wan, Linhong Mo, Aixian Liu
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Abstract
Introduction
Ischemic stroke is a leading cause of death and chronic disability worldwide. Therapeutic options to reduce stroke-related disability are still limited. Resident astrocytes are the most abundant glial cells in the brain and respond to the pathophysiological changes induced by ischemic stroke.
Methods
Comprehensive literature search and narrative review to summarize the current field of astrocytes in poststroke rehabilitation using the PubMed database.
Results
This review first presents that astrocyte activation is critical for scar formation, synaptogenesis, synaptic remodeling, inflammation limitation, and metabolic regulation. Next, we summarize the contributions of astrocytes to neural repair after stroke with a focus on their effects on exercise, transcranial magnetic stimulation (TMS), transcranial electrical stimulation (tES), music therapy, acupuncture, hyperbaric oxygen therapy (HBOT), and enriched environment (EE).
Conclusions
In this review, we comprehensively analyze the role and possible mechanisms of astrocytes in various rehabilitative treatments and suggest that targeting astrocytes may be an effective strategy for the development of innovative therapeutic strategies for ischemic stroke.
期刊介绍：
Brain and Behavior is supported by other journals published by Wiley, including a number of society-owned journals. The journals listed below support Brain and Behavior and participate in the Manuscript Transfer Program by referring articles of suitable quality and offering authors the option to have their paper, with any peer review reports, automatically transferred to Brain and Behavior.
* [Acta Psychiatrica Scandinavica](https://publons.com/journal/1366/acta-psychiatrica-scandinavica)
* [Addiction Biology](https://publons.com/journal/1523/addiction-biology)
* [Aggressive Behavior](https://publons.com/journal/3611/aggressive-behavior)
* [Brain Pathology](https://publons.com/journal/1787/brain-pathology)
* [Child: Care, Health and Development](https://publons.com/journal/6111/child-care-health-and-development)
* [Criminal Behaviour and Mental Health](https://publons.com/journal/3839/criminal-behaviour-and-mental-health)
* [Depression and Anxiety](https://publons.com/journal/1528/depression-and-anxiety)
* Developmental Neurobiology
* [Developmental Science](https://publons.com/journal/1069/developmental-science)
* [European Journal of Neuroscience](https://publons.com/journal/1441/european-journal-of-neuroscience)
* [Genes, Brain and Behavior](https://publons.com/journal/1635/genes-brain-and-behavior)
* [GLIA](https://publons.com/journal/1287/glia)
* [Hippocampus](https://publons.com/journal/1056/hippocampus)
* [Human Brain Mapping](https://publons.com/journal/500/human-brain-mapping)
* [Journal for the Theory of Social Behaviour](https://publons.com/journal/7330/journal-for-the-theory-of-social-behaviour)
* [Journal of Comparative Neurology](https://publons.com/journal/1306/journal-of-comparative-neurology)
* [Journal of Neuroimaging](https://publons.com/journal/6379/journal-of-neuroimaging)
* [Journal of Neuroscience Research](https://publons.com/journal/2778/journal-of-neuroscience-research)
* [Journal of Organizational Behavior](https://publons.com/journal/1123/journal-of-organizational-behavior)
* [Journal of the Peripheral Nervous System](https://publons.com/journal/3929/journal-of-the-peripheral-nervous-system)
* [Muscle & Nerve](https://publons.com/journal/4448/muscle-and-nerve)
* [Neural Pathology and Applied Neurobiology](https://publons.com/journal/2401/neuropathology-and-applied-neurobiology)
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