WS07.05Indirect evaluation of lung condition by means of low field nuclear magnetic resonance following chest physiotherapy or modulator drug administration in cystic fibrosis patients

IF 5.4 2区医学 Q1 RESPIRATORY SYSTEM

Journal of Cystic Fibrosis Pub Date : 2025-06-01 DOI:10.1016/j.jcf.2025.03.532

M. Abrami , A. Biasin , M. Maschio , M. Conese , M. Confalonieri , F. Gerin , F. Salton , P. Confalonieri , B. Ruaro , G. Grassi , M. Grassi

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引用次数: 0

Abstract

Objectives

as most cystic fibrosis (CF) patients progress to respiratory failure, lung functionality assessment is pivotal. We previously developed a test that monitors airways condition measuring the spin-spin relaxation time (T_2m) of the water hydrogens present in sputum by Low Field-Nuclear Magnetic Resonance (LF-NMR). This study further investigates the significance of T_2m by exploring: 1) influence on T_2m of sputum contamination by saliva, 2) T_2m relation with sputum mesh size, 3) correlation with the effects of chest physiotherapy (CP) and of the cystic fibrosis transmembrane conductance regulator (CFTR) modulator elexacaftor/tezacaftor/ivacaftor (ETI).

Methods

T_2m was measured in the sputum of 16 CF patients before/after CP and in 9/16 patients before/after ETI administration. FEV₁/C reactive protein (CRP)/erythrocyte-sedimentation rate (ESR) and sweat chloride concentration were measured by standard techniques. Sputum contamination by saliva/sputum mesh size were determined mathematically.

Results

We present a novel mathematical approach to correct T_2m values in sputum samples contaminated by saliva and to determine T_2m relation to sputum mesh size. Additionally, we prove that T_2m detects the lack of significant effects on lung function by CP (confirmed by FEV₁). Moreover, T_2m detects the ETI positive effects on lung function (evaluated by FEV₁) and inversely correlates with the CRP/ESR/chloride sweat concentration.

Conclusion

These data strengthen the rationale for T_2m employment in CF lung disease monitoring.

查看原文本刊更多论文

ws07.05应用低场核磁共振间接评价囊性纤维化患者胸部物理治疗或调节药物治疗后肺部状况

目的随着囊性纤维化（CF）患者进展为呼吸衰竭，肺功能评估是关键。我们之前开发了一种测试，通过低场核磁共振（LF-NMR）测量痰中存在的水氢的自旋-自旋弛豫时间（T2m）来监测气道状况。本研究通过探讨：1)唾液污染对T2m的影响，2)T2m与痰网大小的关系，3)胸部物理治疗（CP）和囊性纤维化跨膜传导调节剂（CFTR）的作用相关性，进一步探讨T2m的意义。方法测定16例CF患者CP前后和9/16例给予ETI前后痰液中st2m的含量。采用标准技术测定FEV1/C反应蛋白(CRP)/红细胞沉降率（ESR）和汗液氯化物浓度。用数学方法测定唾液污染/痰网大小。结果我们提出了一种新的数学方法来校正唾液污染的痰样本中的T2m值，并确定T2m与痰网尺寸的关系。此外，我们证明T2m检测到CP对肺功能没有显著影响（通过FEV1证实）。此外，T2m检测ETI对肺功能的积极影响（通过FEV1评估），并与CRP/ESR/氯化物汗液浓度呈负相关。结论这些数据加强了在CF肺部疾病监测中使用T2m的理由。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Cystic Fibrosis 医学-呼吸系统

CiteScore

10.10

自引率

13.50%

发文量

1361

审稿时长

50 days

期刊介绍： The Journal of Cystic Fibrosis is the official journal of the European Cystic Fibrosis Society. The journal is devoted to promoting the research and treatment of cystic fibrosis. To this end the journal publishes original scientific articles, editorials, case reports, short communications and other information relevant to cystic fibrosis. The journal also publishes news and articles concerning the activities and policies of the ECFS as well as those of other societies related the ECFS.