ACE2/Angiotensin-(1-7)/Mas and the brain

IF 2.7 4区医学 Q3 NEUROSCIENCES

Brain Research Pub Date : 2025-05-31 DOI:10.1016/j.brainres.2025.149739

Maria José Campagnole-Santos , Marco Antônio Peliky Fontes , Thiago Verano-Braga , Andrea Siqueira Haibara , Michael Bader , Robson A.S. Santos

引用次数: 0

Abstract

It is well known that the renin-angiotensin system (RAS) plays a key role in regulating blood pressure and hydroelectrolyte balance. In addition to angiotensin (Ang) II, Ang-(1-7) has emerged as an important component of this system. Here we review evidence regarding the presence and actions of ACE2/Ang-(1-7)/Mas receptor pathway within the central nervous system, where the RAS possesses a crucial role in controlling cardiovascular, metabolic and stress-coping behavior functions. The involvement of this non-canonical RAS pathway in the brain mechanisms related to hypertension will also be discussed.

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ACE2/血管紧张素-(1-7)/Mas与脑的关系

众所周知，肾素-血管紧张素系统（RAS）在调节血压和水电解质平衡中起着关键作用。除了血管紧张素（Ang） II外，Ang-(1-7)已成为该系统的重要组成部分。本文综述了中枢神经系统中ACE2/Ang-(1-7)/Mas受体通路的存在和作用，其中RAS在控制心血管、代谢和应激应对行为功能中起着至关重要的作用。我们还将讨论这种非规范RAS通路在高血压相关脑机制中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Brain Research 医学-神经科学

CiteScore

5.90

自引率

3.40%

发文量

268

审稿时长

47 days

期刊介绍： An international multidisciplinary journal devoted to fundamental research in the brain sciences. Brain Research publishes papers reporting interdisciplinary investigations of nervous system structure and function that are of general interest to the international community of neuroscientists. As is evident from the journals name, its scope is broad, ranging from cellular and molecular studies through systems neuroscience, cognition and disease. Invited reviews are also published; suggestions for and inquiries about potential reviews are welcomed. With the appearance of the final issue of the 2011 subscription, Vol. 67/1-2 (24 June 2011), Brain Research Reviews has ceased publication as a distinct journal separate from Brain Research. Review articles accepted for Brain Research are now published in that journal.