The potential role of probiotics and their bioactive compounds in the management of pulmonary tuberculosis

IF 4.7 3区医学 Q1 INFECTIOUS DISEASES

Journal of Infection and Public Health Pub Date : 2025-05-24 DOI:10.1016/j.jiph.2025.102840

Hamed Memariani , Mojtaba Memariani , Seyed Ebrahim Eskandari , Abdolmajid Ghasemian , Ali Nour Neamatollahi

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Abstract

The significance of gut microbiota in human health is well recognized, yet its effects on pulmonary infectious diseases like tuberculosis (TB) are not thoroughly comprehended. While anti-TB drugs and preventive strategies are indispensable, the incorporation of adjunct therapies, including probiotics and their bioactive compounds, could provide potential biotherapeutic benefits. This review strives to collate the recent experimental and clinical investigations into the manipulation of the gut microbiome through probiotics, exploring their potential to sustain eubiosis, enhance recovery from TB, and mitigate the adverse effects of anti-TB therapies. The multi-pronged mechanisms by which probiotics act against M. tuberculosis include their immunomodulatory properties, the promotion of autophagy, direct inhibition of the pathogen growth via bacteriocin production, the reduction of adverse effects from anti-TB drugs, and a diminished risk of comorbidities. Future research should prioritize high-quality randomized controlled trials that integrate omics with personalized microbiome-based therapeutic approaches to combat TB.

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益生菌及其生物活性化合物在肺结核治疗中的潜在作用

肠道菌群对人类健康的重要性已得到充分认识，但其对肺结核（TB）等肺部传染病的影响尚未完全了解。虽然抗结核药物和预防策略是必不可少的，但结合辅助疗法，包括益生菌及其生物活性化合物，可以提供潜在的生物治疗益处。本综述旨在整理最近通过益生菌操纵肠道微生物组的实验和临床研究，探索其维持益生菌，促进结核病恢复和减轻抗结核治疗不良反应的潜力。益生菌对结核分枝杆菌起作用的多管齐下的机制包括其免疫调节特性、促进自噬、通过细菌素的产生直接抑制病原体生长、减少抗结核药物的不良反应以及降低合并症的风险。未来的研究应优先考虑高质量的随机对照试验，将组学与基于个性化微生物组的治疗方法结合起来，以对抗结核病。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Infection and Public Health PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH -INFECTIOUS DISEASES

CiteScore

13.10

自引率

1.50%

发文量

203

审稿时长

96 days

期刊介绍： The Journal of Infection and Public Health, first official journal of the Saudi Arabian Ministry of National Guard Health Affairs, King Saud Bin Abdulaziz University for Health Sciences and the Saudi Association for Public Health, aims to be the foremost scientific, peer-reviewed journal encompassing infection prevention and control, microbiology, infectious diseases, public health and the application of healthcare epidemiology to the evaluation of health outcomes. The point of view of the journal is that infection and public health are closely intertwined and that advances in one area will have positive consequences on the other. The journal will be useful to all health professionals who are partners in the management of patients with communicable diseases, keeping them up to date. The journal is proud to have an international and diverse editorial board that will assist and facilitate the publication of articles that reflect a global view on infection control and public health, as well as emphasizing our focus on supporting the needs of public health practitioners. It is our aim to improve healthcare by reducing risk of infection and related adverse outcomes by critical review, selection, and dissemination of new and relevant information in the field of infection control, public health and infectious diseases in all healthcare settings and the community.