Recent advances on the syntheses of oligosaccharides and the corresponding glycoconjugates towards development of vaccine candidates against invasive Neisseria meningitidis strains

IF 2.4 3区化学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Carbohydrate Research Pub Date : 2025-05-29 DOI:10.1016/j.carres.2025.109545

Nabamita Basu , Mana Mohan Mukherjee , Rina Ghosh

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引用次数: 0

Abstract

Neisseria meningitidis

(Men) is one of the reasons of meningitis and sepsis worldwide. Mainly affected groups are children below five years and adolescents. Out of thirteen different Men-serogroups, disease causing invasive ones are the following six groups: A, B, C, W, X and Y. Epidemics and outbreaks by Men-strains are also reported to occur in several countries around the world. Based on the capsular polysaccharides of Men-strains (A, C, W and Y) conjugated with carrier proteins [Diphtheria toxoid (DT), CRM197 (a non-toxic mutant of DT) or Tetanus toxoid (TT)], several mono- and multi-valent vaccines were developed and licensed, which are still being used. Vaccines in the market against serogroup B are derived from MenB-proteins. Apart from these, several synthetic or semi-synthetic glycoconjugate-vaccine candidates against the disease-causing Men-serogroups are still under development or under pre-clinical or clinical trials. This minireview will encompass an overview mainly of the chemical syntheses of such semi-synthetic or synthetic glycoconjugates as Men-vaccine candidates.

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低聚糖合成及其糖缀合物在开发抗侵袭性脑膜炎奈瑟菌候选疫苗方面的最新进展

脑膜炎奈瑟菌（男性）是全世界脑膜炎和败血症的原因之一。主要受影响的群体是五岁以下儿童和青少年。在13种不同的man -血清群中，引起疾病的侵袭性病毒有以下6种：A、B、C、W、X和Y.据报道，在世界上一些国家也发生了由men -菌株引起的流行病和暴发。基于men -菌株（A， C， W和Y）的荚膜多糖与载体蛋白[白喉类毒素（DT）， CRM197 （DT的无毒突变体）或破伤风类毒素（TT）]结合，开发并许可了几种单价和多价疫苗，这些疫苗仍在使用中。市场上针对血清B群的疫苗是从menb蛋白中提取的。除此之外，几种针对男性致病血清群的合成或半合成糖结合物候选疫苗仍在开发中，或正在进行临床前或临床试验。这篇小型综述将主要包括半合成或合成糖缀合物作为men -候选疫苗的化学合成。

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来源期刊

Carbohydrate Research 化学-生化与分子生物学

CiteScore

5.00

自引率

3.20%

发文量

183

审稿时长

3.6 weeks

期刊介绍： Carbohydrate Research publishes reports of original research in the following areas of carbohydrate science: action of enzymes, analytical chemistry, biochemistry (biosynthesis, degradation, structural and functional biochemistry, conformation, molecular recognition, enzyme mechanisms, carbohydrate-processing enzymes, including glycosidases and glycosyltransferases), chemical synthesis, isolation of natural products, physicochemical studies, reactions and their mechanisms, the study of structures and stereochemistry, and technological aspects. Papers on polysaccharides should have a "molecular" component; that is a paper on new or modified polysaccharides should include structural information and characterization in addition to the usual studies of rheological properties and the like. A paper on a new, naturally occurring polysaccharide should include structural information, defining monosaccharide components and linkage sequence. Papers devoted wholly or partly to X-ray crystallographic studies, or to computational aspects (molecular mechanics or molecular orbital calculations, simulations via molecular dynamics), will be considered if they meet certain criteria. For computational papers the requirements are that the methods used be specified in sufficient detail to permit replication of the results, and that the conclusions be shown to have relevance to experimental observations - the authors'' own data or data from the literature. Specific directions for the presentation of X-ray data are given below under Results and "discussion".