Prevalence of migraine in individuals with functional seizures: A systematic review and meta-analysis

IF 2 4区医学 Q3 CLINICAL NEUROLOGY

Epilepsy Research Pub Date : 2025-05-30 DOI:10.1016/j.eplepsyres.2025.107596

Gaziz Kyrgyzbay , Dina Kalinina , Ruslan Akhmedullin , Zhassulan Utebekov , Asemgul Kasenova , Raffaele Ornello , Darkhan Kimadiev , Guldana Zhumabayeva

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引用次数: 0

Abstract

Background

This study aimed to understand the prevalence of migraine in patients with functional seizures in general, as well as compared to patients with epileptic seizures.

Methods

We conducted a literature search of the PubMed, Scopus, and Web of Science databases from database inception until July, 2024. We identified studies using an observational design and performed a meta-analysis to evaluate the association between migraines and functional seizures. We assessed the quality of the studies with the Newcastle-Ottawa Scale, and identified the pooled odds ratios (OR) and mean differences. Heterogeneity was investigated using the I² statistic, significance was determined using Cochran's test, and a post-hoc Begg's test was performed. This study was registered with PROSPERO (CRD42024558536).

Results

Of the 3248 studies identified, 13 studies (N = 2415) were eligible for inclusion. Out of 2415 patients with functional seizures, 763 (31.5 %) patients had comorbid migraine. The pooled OR for prevalence of migraine in individuals with functional seizures compared with those with epileptic seizures was 2.77 (95 % CI: 2.36–3.27), with a corresponding mean difference of 18 % ((95 % CI: 9 %-27 %). Quality assessment revealed moderate-to-high quality in all the included studies.

Conclusion

This study revealed a high prevalence of migraine in patients with functional seizures. However, existing evidence is limited to a handful of observational studies. More studies are needed to evaluate the direction of the association and the clinical and therapeutic impact of migraine on functional seizures.

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偏头痛在功能性癫痫患者中的患病率：一项系统回顾和荟萃分析

本研究旨在了解偏头痛在功能性癫痫发作患者中的患病率，并与癫痫发作患者进行比较。方法对PubMed、Scopus和Web of Science数据库从建库到2024年7月的文献进行检索。我们确定了采用观察设计的研究，并进行了荟萃分析，以评估偏头痛和功能性癫痫发作之间的关系。我们用纽卡斯尔-渥太华量表评估了研究的质量，并确定了合并优势比（OR）和平均差异。采用I²统计量调查异质性，采用Cochran检验确定显著性，并进行事后Begg检验。本研究已在PROSPERO注册（CRD42024558536）。结果在3248项研究中，13项研究（N = 2415）符合纳入条件。在2415例功能性癫痫发作患者中，763例（31.5 %）患者伴有偏头痛。与癫痫发作患者相比，功能性癫痫发作患者偏头痛患病率的合并OR为2.77(95 % CI: 2.36-3.27)，相应的平均差异为18 %（95 % CI: 9 %-27 %）。质量评估显示所有纳入研究的质量均为中等至高。结论本研究揭示了偏头痛在功能性癫痫发作患者中的高患病率。然而，现有的证据仅限于少数观察性研究。需要更多的研究来评估偏头痛与功能性癫痫发作之间的关系以及偏头痛对临床和治疗的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Epilepsy Research 医学-临床神经学

CiteScore

0.10

自引率

4.50%

发文量

143

审稿时长

62 days

期刊介绍： Epilepsy Research provides for publication of high quality articles in both basic and clinical epilepsy research, with a special emphasis on translational research that ultimately relates to epilepsy as a human condition. The journal is intended to provide a forum for reporting the best and most rigorous epilepsy research from all disciplines ranging from biophysics and molecular biology to epidemiological and psychosocial research. As such the journal will publish original papers relevant to epilepsy from any scientific discipline and also studies of a multidisciplinary nature. Clinical and experimental research papers adopting fresh conceptual approaches to the study of epilepsy and its treatment are encouraged. The overriding criteria for publication are novelty, significant clinical or experimental relevance, and interest to a multidisciplinary audience in the broad arena of epilepsy. Review articles focused on any topic of epilepsy research will also be considered, but only if they present an exceptionally clear synthesis of current knowledge and future directions of a research area, based on a critical assessment of the available data or on hypotheses that are likely to stimulate more critical thinking and further advances in an area of epilepsy research.