Pyrazine-Functionalized Bio-MOFs for Selective Luminescence Sensing of Colchicine and Nitrofurazone in Aqueous Solutions

IF 4.3 2区化学 Q1 CHEMISTRY, INORGANIC & NUCLEAR

Inorganic Chemistry Pub Date : 2025-06-02 DOI:10.1021/acs.inorgchem.5c01125

Fei-Long Luo, Hao-Bo Wang, Kun Wu, Dong Luo, Yifang Zhao, Yong-Liang Huang, Weigang Lu

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Abstract

By employing a mix-linker strategy, we have successfully synthesized two isostructural anionic microporous biological metal–organic frameworks (Bio-MOFs), showing excellent chemical stability across a pH range of 3–14 in the aqueous phase. Luminescence titration studies reveal that replacing the benzene core of the carboxylate linker with pyrazine leads to markedly enhanced energy transfer from the linker to the metal cluster, significantly increasing the emission intensity. This linker engineering strategy endows the MOF with superior performance in antibiotic sensing with limits of detection of 1.5 μM for colchicine (COL) and 0.8 μM for nitrofurazone (NFZ). Additionally, the title MOF exhibited selective detection of COL and NFZ in the presence of potential interfering species, including other antibiotics or serum species. Moreover, a mixed matrix film was fabricated by dispersing the MOF crystalline powders on a polycaprolactone sheet, demonstrating real-time on-site monitoring of COL and NFZ in aqueous solutions.

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吡嗪功能化生物mofs对水溶液中秋水仙碱和硝基呋喃酮的选择性发光传感

通过采用混合连接策略，我们成功地合成了两种阴离子微孔生物金属有机骨架（Bio-MOFs），在pH为3-14的水相中表现出优异的化学稳定性。发光滴定研究表明，用吡嗪取代羧酸酯连接剂的苯核，可以显著增强连接剂向金属团簇的能量传递，显著提高发射强度。这种连接体工程策略使MOF在抗生素传感方面具有优异的性能，秋水仙碱（COL）的检测限为1.5 μM，硝基呋喃酮（NFZ）的检测限为0.8 μM。此外，标题MOF在潜在干扰物种（包括其他抗生素或血清物种）存在的情况下表现出对COL和NFZ的选择性检测。此外，通过将MOF晶体粉末分散在聚己内酯片上制备混合基质膜，演示了水溶液中COL和NFZ的实时现场监测。

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来源期刊

Inorganic Chemistry 化学-无机化学与核化学

CiteScore

7.60

自引率

13.00%

发文量

1960

审稿时长

1.9 months

期刊介绍： Inorganic Chemistry publishes fundamental studies in all phases of inorganic chemistry. Coverage includes experimental and theoretical reports on quantitative studies of structure and thermodynamics, kinetics, mechanisms of inorganic reactions, bioinorganic chemistry, and relevant aspects of organometallic chemistry, solid-state phenomena, and chemical bonding theory. Emphasis is placed on the synthesis, structure, thermodynamics, reactivity, spectroscopy, and bonding properties of significant new and known compounds.