A soft robotic total artificial hybrid heart

IF 14.7 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Nature Communications Pub Date : 2025-06-03 DOI:10.1038/s41467-025-60372-6

Maziar Arfaee, Annemijn Vis, Paul A. A. Bartels, Lucas C. van Laake, Lucrezia Lorenzon, Dina M. Ibrahim, Debora Zrinscak, Anthal I. P. M. Smits, Andreas Henseler, Matteo Cianchetti, Patricia Y. W. Dankers, Carlijn V. C. Bouten, Johannes T. B. Overvelde, Jolanda Kluin

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Abstract

End-stage heart failure is a deadly disease. Current total artificial hearts (TAHs) carry high mortality and morbidity and offer low quality of life. To overcome current biocompatibility issues, we propose the concept of a soft robotic, hybrid (pumping power comes from soft robotics, innerlining from the patient’s own cells) TAH. The device features a pneumatically driven actuator (septum) between two ventricles and is coated with supramolecular polymeric materials to promote anti-thrombotic and tissue engineering properties. In vitro, the Hybrid Heart pumps 5.7 L/min and mimics the native heart’s adaptive function. Proof-of-concept studies in rats and an acute goat model demonstrate the Hybrid Heart’s potential for clinical use and improved biocompatibility. This paper presents the first proof-of-concept of a soft, biocompatible TAH by providing a platform using soft robotics and tissue engineering to create new horizons in heart failure and transplantation medicine.

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一个柔软的机器人全人工混合心脏

终末期心力衰竭是一种致命疾病。目前全人工心脏（TAHs）具有高死亡率和发病率，并提供低生活质量。为了克服目前的生物相容性问题，我们提出了一种软机器人的概念，混合（泵送动力来自软机器人，内层来自患者自身细胞）TAH。该装置的特点是在两个心室之间有一个气动驱动器（隔膜），并涂有超分子聚合物材料，以提高抗血栓和组织工程性能。在体外，混合心脏泵速为5.7升/分钟，并模仿天然心脏的适应功能。在大鼠和急性山羊模型中进行的概念验证研究证明了混合心脏在临床应用和改善生物相容性方面的潜力。本文通过提供一个使用软机器人技术和组织工程的平台，为心力衰竭和移植医学创造了新的视野，首次提出了软的、生物相容性的TAH概念验证。

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来源期刊

Nature Communications Biological Science Disciplines-

CiteScore

24.90

自引率

2.40%

发文量

6928

审稿时长

3.7 months

期刊介绍： Nature Communications, an open-access journal, publishes high-quality research spanning all areas of the natural sciences. Papers featured in the journal showcase significant advances relevant to specialists in each respective field. With a 2-year impact factor of 16.6 (2022) and a median time of 8 days from submission to the first editorial decision, Nature Communications is committed to rapid dissemination of research findings. As a multidisciplinary journal, it welcomes contributions from biological, health, physical, chemical, Earth, social, mathematical, applied, and engineering sciences, aiming to highlight important breakthroughs within each domain.