Regulatory T cell therapies to treat autoimmune diseases and transplant rejection

IF 27.7 1区医学 Q1 IMMUNOLOGY

Nature Immunology Pub Date : 2025-06-02 DOI:10.1038/s41590-025-02154-2

Jeffrey A. Bluestone, Bruce K. Burnett, Christine E. Crute, Mick D. Fellows, Megan Levings, Hervé Lebrec, Lucilia Pereira Mouriès, Jeffrey Rice, Patricia Rohan, Maria Grazia Roncarolo, Daniel Rotrosen

引用次数: 0

Abstract

Regulatory T cell therapies have shown promise for treating autoimmune diseases and aiding transplantation. We summarize a recent NIAID/HESI-sponsored workshop that addressed key issues in non-clinical and clinical development vital to advancing this immune tolerance paradigm.

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调节性T细胞疗法治疗自身免疫性疾病和移植排斥反应

调节性T细胞疗法已显示出治疗自身免疫性疾病和辅助移植的希望。我们总结了最近NIAID/ hesi赞助的研讨会，该研讨会讨论了对推进这种免疫耐受范例至关重要的非临床和临床开发中的关键问题。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Immunology 医学-免疫学

CiteScore

40.00

自引率

2.30%

发文量

248

审稿时长

4-8 weeks

期刊介绍： Nature Immunology is a monthly journal that publishes the highest quality research in all areas of immunology. The editorial decisions are made by a team of full-time professional editors. The journal prioritizes work that provides translational and/or fundamental insight into the workings of the immune system. It covers a wide range of topics including innate immunity and inflammation, development, immune receptors, signaling and apoptosis, antigen presentation, gene regulation and recombination, cellular and systemic immunity, vaccines, immune tolerance, autoimmunity, tumor immunology, and microbial immunopathology. In addition to publishing significant original research, Nature Immunology also includes comments, News and Views, research highlights, matters arising from readers, and reviews of the literature. The journal serves as a major conduit of top-quality information for the immunology community.