Mutated epitopes in SARS-CoV-2 variants are poorly immunogenic

IF 27.7 1区医学 Q1 IMMUNOLOGY

Nature Immunology Pub Date : 2025-06-02 DOI:10.1038/s41590-025-02164-0

引用次数: 0

Abstract

We investigated how previous immunity and intrinsic immunogenicity affect the generation of immune responses to SARS-CoV-2 variants. Although previous immunity partially reduces subtype-specific responses to a new virus variant, we found that poor immunogenicity of the mutated epitopes in the infecting virus has a larger effect on limiting new responses.

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SARS-CoV-2变异体中突变的表位免疫原性较差

我们研究了既往免疫和固有免疫原性如何影响对SARS-CoV-2变体的免疫反应的产生。虽然先前的免疫部分地减少了对新病毒变体的亚型特异性反应，但我们发现感染病毒中突变表位的免疫原性差对限制新反应有更大的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Immunology 医学-免疫学

CiteScore

40.00

自引率

2.30%

发文量

248

审稿时长

4-8 weeks

期刊介绍： Nature Immunology is a monthly journal that publishes the highest quality research in all areas of immunology. The editorial decisions are made by a team of full-time professional editors. The journal prioritizes work that provides translational and/or fundamental insight into the workings of the immune system. It covers a wide range of topics including innate immunity and inflammation, development, immune receptors, signaling and apoptosis, antigen presentation, gene regulation and recombination, cellular and systemic immunity, vaccines, immune tolerance, autoimmunity, tumor immunology, and microbial immunopathology. In addition to publishing significant original research, Nature Immunology also includes comments, News and Views, research highlights, matters arising from readers, and reviews of the literature. The journal serves as a major conduit of top-quality information for the immunology community.