Succinate undermines FOXP3 stability and disrupts Treg cell function

IF 27.7 1区医学 Q1 IMMUNOLOGY

Nature Immunology Pub Date : 2025-06-02 DOI:10.1038/s41590-025-02167-x

Ye Zheng

引用次数: 0

Abstract

Increased levels of succinate in individuals with inflammatory bowel disease suppress succinylation of the transcription factor FOXP3, leading to its increased ubiquitination and degradation in intestinal regulatory T cells. This process exacerbates colon inflammation and contributes to disease progression.

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琥珀酸破坏FOXP3的稳定性，破坏Treg细胞的功能

炎症性肠病患者琥珀酸水平升高抑制转录因子FOXP3的琥珀酸化，导致其泛素化和肠道调节性T细胞降解增加。这一过程加剧了结肠炎症并导致疾病进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Immunology 医学-免疫学

CiteScore

40.00

自引率

2.30%

发文量

248

审稿时长

4-8 weeks

期刊介绍： Nature Immunology is a monthly journal that publishes the highest quality research in all areas of immunology. The editorial decisions are made by a team of full-time professional editors. The journal prioritizes work that provides translational and/or fundamental insight into the workings of the immune system. It covers a wide range of topics including innate immunity and inflammation, development, immune receptors, signaling and apoptosis, antigen presentation, gene regulation and recombination, cellular and systemic immunity, vaccines, immune tolerance, autoimmunity, tumor immunology, and microbial immunopathology. In addition to publishing significant original research, Nature Immunology also includes comments, News and Views, research highlights, matters arising from readers, and reviews of the literature. The journal serves as a major conduit of top-quality information for the immunology community.