{"title":"Fungicidal Efficacy of Amphotericin B and Micafungin Against Candida auris Within Macrophage.","authors":"Fujiang Zhao, Azusa Takahashi-Nakaguchi, Michiyo Okamoto, Kaname Sasamoto, Masashi Yamaguchi, Hiroji Chibana","doi":"10.3314/mmj.24-00029","DOIUrl":null,"url":null,"abstract":"<p><p>Candida auris poses a significant therapeutic challenge due to its resistance to azoles echinocandins and amphotericin B (AMPH-B). While C. auris strains are known to exhibit high survival rates within macrophages the susceptibility of phagocytosed cells to antifungal agents remains unclear. To address this, we evaluated the fungicidal effects of AMPH-B and micafungin (MCFG) on C. auris strains from four distinct clades within macrophages. Our results suggested that both AMPH-B and MCFG retain fungicidal activity against the C. auris strains after being phagocytosed by macrophages providing insights into the intracellular activity of these antifungal agents.</p>","PeriodicalId":520314,"journal":{"name":"Medical mycology journal","volume":"66 2","pages":"45-50"},"PeriodicalIF":0.0000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Medical mycology journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3314/mmj.24-00029","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Candida auris poses a significant therapeutic challenge due to its resistance to azoles echinocandins and amphotericin B (AMPH-B). While C. auris strains are known to exhibit high survival rates within macrophages the susceptibility of phagocytosed cells to antifungal agents remains unclear. To address this, we evaluated the fungicidal effects of AMPH-B and micafungin (MCFG) on C. auris strains from four distinct clades within macrophages. Our results suggested that both AMPH-B and MCFG retain fungicidal activity against the C. auris strains after being phagocytosed by macrophages providing insights into the intracellular activity of these antifungal agents.
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