Enhanced bactericidal activity of selenosteroid complexes with zinc, copper, and cobalt against resistant bacterial strains

IF 2.5 2区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Steroid Biochemistry and Molecular Biology Pub Date : 2025-05-30 DOI:10.1016/j.jsbmb.2025.106793

Marta Malinowska , Sławomir Wojtulewski , Joanna Wysocka , Damian Zarzecki , Karolina H. Markiewicz , Beata Kalska-Szostko , Urszula Wnorowska , Robert Bucki , Izabella Jastrzebska

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引用次数: 0

Abstract

Let's enhance the activity of selenosteroids! For this purpose, we have obtained a new class of metal complexes with the steroid β-hydroxy-phenylselenide as a model ligand using a simple and efficient methodology. The obtained compounds were characterised by ¹H and ⁷⁷Se nuclear magnetic resonance spectroscopy, infra-red spectroscopy, mass spectra, X-ray diffraction and thermogravimetric analysis. The bactericidal activity of the complexes against Pseudomonas aeruginosa and Staphylococcus aureus was then evaluated using a standard killing assay. The results showed that the copper and cobalt complexes with selenosteroid exhibited significant bactericidal activity against P. aeruginosa. The presented synthetic method shows potential for obtaining compounds that may be effective in treating infections caused by these clinically relevant bacterial strains.

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硒类固醇配合物与锌、铜和钴对耐药菌株的杀菌活性增强。

让我们增强硒类固醇的活性吧！为此，我们用一种简单有效的方法获得了一类以类固醇β-羟基苯基硒化物为模型配体的新型金属配合物。通过1H和77Se核磁共振谱、红外谱、质谱、x射线衍射和热重分析对所得化合物进行了表征。然后用标准的杀灭试验评价该复合物对铜绿假单胞菌和金黄色葡萄球菌的杀菌活性。结果表明，铜钴配合物与硒类固醇配合物对铜绿假单胞菌具有明显的杀菌活性。所提出的合成方法显示出获得可能有效治疗由这些临床相关菌株引起的感染的化合物的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Steroid Biochemistry and Molecular Biology 生物-内分泌学与代谢

CiteScore

8.60

自引率

2.40%

发文量

113

审稿时长

46 days

期刊介绍： The Journal of Steroid Biochemistry and Molecular Biology is devoted to new experimental and theoretical developments in areas related to steroids including vitamin D, lipids and their metabolomics. The Journal publishes a variety of contributions, including original articles, general and focused reviews, and rapid communications (brief articles of particular interest and clear novelty). Selected cutting-edge topics will be addressed in Special Issues managed by Guest Editors. Special Issues will contain both commissioned reviews and original research papers to provide comprehensive coverage of specific topics, and all submissions will undergo rigorous peer-review prior to publication.