The Prognosis Predictive Value of Tumor Depth of Invasion on the Clinical Outcomes of Oral Squamous Cell Carcinoma Patients.

IF 0.6 Q4 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Maxillofacial & Oral Surgery Pub Date : 2025-06-01 Epub Date: 2025-04-08 DOI:10.1007/s12663-025-02524-1

Talal Mohamed Ahmed Eltayib Mohamed, Yousif Idris Eltohami

{"title":"The Prognosis Predictive Value of Tumor Depth of Invasion on the Clinical Outcomes of Oral Squamous Cell Carcinoma Patients.","authors":"Talal Mohamed Ahmed Eltayib Mohamed, Yousif Idris Eltohami","doi":"10.1007/s12663-025-02524-1","DOIUrl":null,"url":null,"abstract":"Objectives: This study was conducted for the first time in the Sudan that aimed to assess whether the tumor depth of invasion (DOI) in oral squamous cell carcinoma (OSCC) is a prognosticator for regional nodal metastasis, locoregional recurrence, survival and identify the cutoff point for metastasis.Methods: Descriptive retrospective cross-sectional hospital based study carried out at Khartoum Teaching Dental Hospital (KTDH) and histopathology laboratory, University of Khartoum. Records of patients were retrieved from the archives of KTDH and the histopathological records were retrieved from archival specimens of Oral Pathology laboratory, University of Khartoum. Data of patients who underwent primary radical surgery for OSCC and neck dissection at KTDH were reviewed.Results: A total of 127 cases, 84 were males and 43 were females.Sixty-seven were snuff dippers.Thirty-six of the total number of snuff dippers favored the lower labial vestibule. Lower gingivolabial area was the favorite site for OSCC that encountered in 52 patients. In the present study, 93 of patients presented with stage IV and the predominant grade was well differentiated squamous cell carcinoma that found in 67 patients. There is a high significant association between depth of invasion and recurrence. Among 60 patients who developed recurrence, 55 of them had DOI ≥ 4 mm. From total of 24 patients with DOI > 4 mm, six patients died, and from total of 101 patients with DOI ≥ 4 mm, 62 patients died that indicated a high significant association between depth of invasion and death with a survival period 27.05 ± 23.08 months in patients with DOI ≥ 4 mm and 44.77 ± 19.20 months in patients with DOI < 4 mm. Patients with positive surgical margins were 9.9 timed more likely to develop recurrence.Conclusions: DOI of OSCC is a reliable histological parameter to predict nodal metastasis, locoregional recurrence and survival with 4 mm cutoff point.","PeriodicalId":47495,"journal":{"name":"Journal of Maxillofacial & Oral Surgery","volume":"24 3","pages":"699-706"},"PeriodicalIF":0.6000,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12122402/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Maxillofacial & Oral Surgery","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s12663-025-02524-1","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/4/8 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}

引用次数: 0

Abstract

Objectives: This study was conducted for the first time in the Sudan that aimed to assess whether the tumor depth of invasion (DOI) in oral squamous cell carcinoma (OSCC) is a prognosticator for regional nodal metastasis, locoregional recurrence, survival and identify the cutoff point for metastasis.

Methods: Descriptive retrospective cross-sectional hospital based study carried out at Khartoum Teaching Dental Hospital (KTDH) and histopathology laboratory, University of Khartoum. Records of patients were retrieved from the archives of KTDH and the histopathological records were retrieved from archival specimens of Oral Pathology laboratory, University of Khartoum. Data of patients who underwent primary radical surgery for OSCC and neck dissection at KTDH were reviewed.

Results: A total of 127 cases, 84 were males and 43 were females.Sixty-seven were snuff dippers.Thirty-six of the total number of snuff dippers favored the lower labial vestibule. Lower gingivolabial area was the favorite site for OSCC that encountered in 52 patients. In the present study, 93 of patients presented with stage IV and the predominant grade was well differentiated squamous cell carcinoma that found in 67 patients. There is a high significant association between depth of invasion and recurrence. Among 60 patients who developed recurrence, 55 of them had DOI ≥ 4 mm. From total of 24 patients with DOI > 4 mm, six patients died, and from total of 101 patients with DOI ≥ 4 mm, 62 patients died that indicated a high significant association between depth of invasion and death with a survival period 27.05 ± 23.08 months in patients with DOI ≥ 4 mm and 44.77 ± 19.20 months in patients with DOI < 4 mm. Patients with positive surgical margins were 9.9 timed more likely to develop recurrence.

Conclusions: DOI of OSCC is a reliable histological parameter to predict nodal metastasis, locoregional recurrence and survival with 4 mm cutoff point.

查看原文本刊更多论文

肿瘤浸润深度对口腔鳞状细胞癌临床预后的预测价值。

目的：本研究首次在苏丹进行，旨在评估口腔鳞状细胞癌（OSCC）的肿瘤浸润深度（DOI）是否是区域淋巴结转移、局部复发、生存的预后因素，并确定转移的截止点。方法：在喀土穆教学牙科医院（KTDH）和喀土穆大学组织病理学实验室进行描述性回顾性横断面医院研究。患者资料来源于KTDH档案，组织病理学资料来源于喀土穆大学口腔病理实验室档案标本。我们回顾了在KTDH接受OSCC原发性根治性手术和颈部清扫的患者的资料。结果：共127例，其中男84例，女43例。67人是鼻烟手。总共有36个吸鼻烟的人喜欢下唇前庭。下牙龈区是52例OSCC的好发部位。在本研究中，93例患者表现为IV期，67例患者的主要级别为高分化鳞状细胞癌。在浸润深度和复发之间有高度显著的关联。60例复发患者中有55例DOI≥4 mm。从患者共24 DOI > 4毫米,六名病人死亡,患者和101 DOI≥4毫米,62名患者死亡,这表明高深度之间的显著联系的入侵和死亡患者的生存期27.05±23.08个月DOI≥4毫米和44.77±19.20个月患者DOI结论:DOI OSCC的是一个可靠的组织学参数预测淋巴结的转移,局部区域复发和生存有4毫米的分界点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of Maxillofacial & Oral Surgery DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

1.90

自引率

0.00%

发文量

138

期刊介绍： This journal offers comprehensive coverage of new techniques, important developments and innovative ideas in Oral and Maxillofacial Surgery. Practice-applicable articles help develop the methods used to handle dentoalveolar surgery, facial injuries and deformities, TMJ disorders, oral cancer, jaw reconstruction, anesthesia and analgesia. The journal also includes specifics on new instruments, diagnostic equipment’s and modern therapeutic drugs and devices. Journal of Oral and Maxillofacial Surgery is recommended for first or priority subscription by the Dental Section of the Medical Library Association. Specific topics covered recently have included: ? distraction osteogenesis ? synthetic bone substitutes ? fibroblast growth factors ? fetal wound healing ? skull base surgery ? computer-assisted surgery ? vascularized bone grafts Benefits to authorsWe also provide many author benefits, such as free PDFs, a liberal copyright policy, special discounts on Elsevier publications and much more. Please click here for more information on our author services.