Fibroblast Activation Protein (FAP): A Crucial Modulator of the Microenvironment in Metastatic Melanoma Case.

Abstract

A 55-year-old male with advanced malignant melanoma received surgery, radiotherapy, and chemotherapy. Despite these treatments, [18F]FDG PET/CT showed significant disease progression. Targeted imaging with gallium-68 radiotracers for CXCR4, SSTR₂, and FAP identified biomarkers for personalized therapy. This led to the choice of [177Lu]Lu-FAPI-2286. After the first cycle, the patient reported pain relief, but subsequent imaging revealed rapid brain metastasis. This case highlights the importance of personalized medicine and molecular imaging in treating advanced melanoma.