Brain Metastases From Solid Cancers in 58 Dogs.

IF 1.7 3区 农林科学 Q2 VETERINARY SCIENCES
Samuel Okonji, Federica Rossi, Silvia Sabattini, Massimo Baroni, Federica Poli, Riccardo Zaccone, Simone Perfetti, Gualtiero Gandini, Laura Marconato
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Abstract

Brain metastases (BM) represent an unmet medical need in human medicine, and they are poorly documented in dogs. The aim of this multi-centre retrospective study was to report the clinical characteristics, primary solid cancer histology, advanced imaging findings, treatment modalities and potential prognostic factors in dogs with presumed BM that occurred either at the time of initial diagnosis or during follow-up. BM diagnosis was established through either imaging studies or histologic examination of specimens obtained during necropsy. A total of 58 client-owned dogs with histologically proven solid cancer and BM were included. Clinicopathologic variables, BM characteristics based on imaging and survival post-BM (SPBM) were recorded. Haemangiosarcoma (53.4%) and carcinoma (27.6%) were the most common primary tumour histotypes, followed by melanoma (12.1%) and undifferentiated sarcoma (6.9%). Synchronous BM and solitary BM occurred in 63.8% and 51.7% of dogs, respectively. The prosencephalus was most commonly affected, with 79% of dogs showing neurologic deficits. Antitumoural or palliative treatment was attempted in a minority of dogs, with no improved outcome. The median SPBM was 3 days (range, 1-255). The 3- and 6-month survival rates were 8.6% and 1.7%, respectively. Dogs with haemangiosarcoma (OR: 7.6; 95% CI, 2.2-25.8; p = 0.001) and those with distant metastases at presentation (OR: 16; 95% CI, 4.2-60.9; p < 0.001) had an increased likelihood of developing synchronous BM. Haemangiosarcoma and carcinoma were the tumours most frequently associated with BM, which were more commonly synchronous and symptomatic, with a high incidence of forebrain localization. The prognosis was poor, regardless of the primary cancer type.

58只狗的实体癌脑转移
脑转移(BM)代表了人类医学中未满足的医疗需求,它们在狗身上的记录很少。本多中心回顾性研究的目的是报告在初始诊断或随访期间发生的假定BM犬的临床特征、原发性实体癌组织学、晚期影像学表现、治疗方式和潜在预后因素。脑脊髓炎的诊断是通过影像学检查或尸检标本的组织学检查确定的。共有58只客户拥有的狗被纳入组织学证实的实体癌和BM。记录临床病理变量、BM影像学特征和BM后生存期(SPBM)。血管肉瘤(53.4%)和癌(27.6%)是最常见的原发肿瘤组织类型,其次是黑色素瘤(12.1%)和未分化肉瘤(6.9%)。同步性脑转移和孤立性脑转移发生率分别为63.8%和51.7%。前脑最常受影响,79%的狗表现出神经功能障碍。在少数狗身上尝试了抗肿瘤或姑息治疗,但没有改善结果。SPBM中位数为3天(范围1-255)。3个月和6个月生存率分别为8.6%和1.7%。血管肉瘤犬(OR: 7.6;95% ci, 2.2-25.8;p = 0.001)和出现远处转移的患者(OR: 16;95% ci, 4.2-60.9;p
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来源期刊
Veterinary Medicine and Science
Veterinary Medicine and Science Veterinary-General Veterinary
CiteScore
3.00
自引率
0.00%
发文量
296
期刊介绍: Veterinary Medicine and Science is the peer-reviewed journal for rapid dissemination of research in all areas of veterinary medicine and science. The journal aims to serve the research community by providing a vehicle for authors wishing to publish interesting and high quality work in both fundamental and clinical veterinary medicine and science. Veterinary Medicine and Science publishes original research articles, systematic reviews, meta-analyses, and research methods papers, along with invited editorials and commentaries. Original research papers must report well-conducted research with conclusions supported by the data presented in the paper. We aim to be a truly global forum for high-quality research in veterinary medicine and science, and believe that the best research should be published and made widely accessible as quickly as possible. Veterinary Medicine and Science publishes papers submitted directly to the journal and those referred from a select group of prestigious journals published by Wiley-Blackwell. Veterinary Medicine and Science is a Wiley Open Access journal, one of a new series of peer-reviewed titles publishing quality research with speed and efficiency. For further information visit the Wiley Open Access website.
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