The association between smoking and the occurrence of hyperuricemia: A retrospective cohort study.

IF 1.9 4区医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Tobacco Induced Diseases Pub Date : 2025-05-30 eCollection Date: 2025-01-01 DOI:10.18332/tid/204253

Peihua Li, Xinyu Li, Guosheng Li, Bing Wang, Yudan Liu, Yuedong Zhao, Qing Yu, Zhengnan Gao, Xuhan Liu

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引用次数: 0

Abstract

Introduction: A retrospective cohort study was conducted to study the association between smoking and hyperuricemia (HUA).

Methods: By collecting and analyzing clinical data of 3196 patients with undiagnosed HUA at baseline in Dalian Municipal Central Hospital of China between 1 January 2010 and 1 January 2021, patients were grouped according to baseline smoking status and smoking index (the number of cigarettes smoked per day × number of years of smoking). Cox regression analysis was used to perform univariable and multivariable analyses of factors that may influence the occurrence of HUA. And further stratification was performed.

Results: The median follow-up time was 3.62 years. A total of 485 (15.2%) patients developed HUA (≥420 μmol/L). The incidence of HUA was significantly higher in the smoking group than in the non-smoking group (p<0.05). There was a statistically significant difference in the incidence of HUA between the smoking index 1-4 (>0) groups and the smoking index 0 (0) group (p<0.05). Multifactorial Cox regression analyses were performed separately and after adjustment for relevant influences, the results showed that smoking was an independent risk factor for the occurrence of HUA with a hazard ratio (HR) of 1.38 (95% CI: 1.11-1.72). And the smoking index groups 401-600 and ≥601 were independent risk factors for the occurrence of HUA, with HRs of 1.46 (95% CI: 1.20-1.70) and 1.53 (95% CI: 1.06-2.22), respectively. The further stratified analysis revealed that smoking remained an independent risk factor for the occurrence of HUA in all subgroups, and the smoking index ≥601 group was also an independent risk factor for the occurrence of HUA, with HRs greater than 1 (p<0.05).

Conclusions: Smoking is an independent risk factor for the occurrence of HUA and is independent of gender, whether a woman is menopausal, body mass index (BMI), and alcohol consumption. The smoking index ≥601 was an independent risk factor for the occurrence of HUA.

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吸烟与高尿酸血症发生的关系：一项回顾性队列研究。

摘要：本研究旨在研究吸烟与高尿酸血症（HUA）之间的关系。方法：收集和分析2010年1月1日至2021年1月1日中国大连市中心医院3196例基线期未确诊HUA患者的临床资料，根据基线吸烟状况和吸烟指数（每天吸烟数×吸烟年数）对患者进行分组。采用Cox回归分析对可能影响HUA发生的因素进行单变量和多变量分析。进一步分层。结果：中位随访时间为3.62年。共有485例（15.2%）患者出现HUA（≥420 μmol/L）。吸烟组HUA的发生率明显高于不吸烟组(0)和吸烟指数0(0)组(p)。结论：吸烟是HUA发生的独立危险因素，且与性别、是否绝经、体重指数（BMI）和饮酒量无关。吸烟指数≥601是HUA发生的独立危险因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Tobacco Induced Diseases SUBSTANCE ABUSE-PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

CiteScore

5.30

自引率

5.40%

发文量

审稿时长

12 weeks

期刊介绍： Tobacco Induced Diseases encompasses all aspects of research related to the prevention and control of tobacco use at a global level. Preventing diseases attributable to tobacco is only one aspect of the journal, whose overall scope is to provide a forum for the publication of research articles that can contribute to reducing the burden of tobacco induced diseases globally. To address this epidemic we believe that there must be an avenue for the publication of research/policy activities on tobacco control initiatives that may be very important at a regional and national level. This approach provides a very important "hands on" service to the tobacco control community at a global scale - as common problems have common solutions. Hence, we see ourselves as "connectors" within this global community. The journal hence encourages the submission of articles from all medical, biological and psychosocial disciplines, ranging from medical and dental clinicians, through health professionals to basic biomedical and clinical scientists.