Shilpi Arora, Deepak Kaushik, Mohammad Akhlaquer Rahman, Rohit Dutt, Abhishek Tiwari, Sarita Garg, Rajeev K Singla, Vineet Mittal
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引用次数: 0
Abstract
Aim: The present research aimed to develop a transdermal formulation of Curcuminoids utilizing eucalyptus oil as a permeation enhancer.
Material & method: Design-based optimization studies were performed to select the concentration of excipients and to prepare the nano emulsion. The eucalyptus oil was selected to develop the curcuminoids emulgel. The developed emulgel was evaluated for permeation using human skin and analyzed by HPLC. The emulgel was also evaluated for anti-inflammatory potential as compared to Curcuminoid gel formulation without permeation enhancer.
Results: Permeability studies performed using human skin with subsequent analysis of the samples by HPLC revealed that developed formulation was three times better as compared to formulation without permeation enhancer. The enhanced penetration attributed to polarity alteration, liquidation, and disruption of lipid bilayer by the terpenes present in essential oils. Literature also suggested that monoterpenes like 1,8 cineole could disrupt the lipid bilayer of skin and thus result in better penetration. The improved permeability could also be responsible for the enhanced anti-inflammatory potential (p < 0.01) of the developed nano-emulgel.
Conclusion: In nutshell, we can conclude that curcuminoids have the potential to be developed as emulgel with eucalyptus oil as a penetration enhancer.
期刊介绍：
Delivering therapeutics in a way that is right for the patient - safe, painless, reliable, targeted, efficient and cost effective - is the fundamental aim of scientists working in this area. Correspondingly, this evolving field has already yielded a diversity of delivery methods, including injectors, controlled release formulations, drug eluting implants and transdermal patches. Rapid technological advances and the desire to improve the efficacy and safety profile of existing medications by specific targeting to the site of action, combined with the drive to improve patient compliance, continue to fuel rapid research progress. Furthermore, the emergence of cell-based therapeutics and biopharmaceuticals such as proteins, peptides and nucleotides presents scientists with new and exciting challenges for the application of therapeutic delivery science and technology. Successful delivery strategies increasingly rely upon collaboration across a diversity of fields, including biology, chemistry, pharmacology, nanotechnology, physiology, materials science and engineering. Therapeutic Delivery recognizes the importance of this diverse research platform and encourages the publication of articles that reflect the highly interdisciplinary nature of the field. In a highly competitive industry, Therapeutic Delivery provides the busy researcher with a forum for the rapid publication of original research and critical reviews of all the latest relevant and significant developments, and focuses on how the technological, pharmacological, clinical and physiological aspects come together to successfully deliver modern therapeutics to patients. The journal delivers this essential information in concise, at-a-glance article formats that are readily accessible to the full spectrum of therapeutic delivery researchers.
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