Glutathione peroxidase activity in Alzheimer's disease patients: A systematic review and meta-analysis.

IF 3.1 3区医学 Q2 NEUROSCIENCES

Journal of Alzheimer's Disease Pub Date : 2025-06-02 DOI:10.1177/13872877251346981

Meire Ellen Pereira, Júlia Vicentin de Souza, Gabriella Giandotti Gomar, Isabeli Lopes Kruk, Cláudia Sirlene Oliveira

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Abstract

BackgroundOxidative stress can trigger and even aggravate Alzheimer's disease (AD). Glutathione peroxidase (GPX) can regulate oxidative stress by controlling the accumulation of hydrogen peroxide.ObjectiveThis study aimed to evaluate the GPX activity in patients with AD through a systematic review and meta-analysis.MethodsFollowing the PRISMA guidelines, data were retrieved from four electronic databases, including those containing cohort and case-control studies, published up to December 2024. Statistical analyses were conducted using RevMan, and risk of bias was evaluated with the Newcastle-Ottawa Scale.ResultsA total of 1999 scientific papers were collected, and 30 papers were included in this systematic review; 20 were included in the meta-analysis. GPX activity was measured in different tissues, such as erythrocytes, plasma, and postmortem brain. The analyses showed that erythrocytes and plasma GPX activity in most studies were inhibited in AD patients compared to healthy controls.ConclusionsThe analyses showed that GPX activity was decreased in AD patients compared to healthy controls in most of the included studies. More detailed research is needed to better assess the effects of GPX activity on AD-associated cognitive impairment and oxidative stress.

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阿尔茨海默病患者谷胱甘肽过氧化物酶活性：系统回顾和荟萃分析。

背景氧化应激可引发甚至加重阿尔茨海默病（AD）。谷胱甘肽过氧化物酶（GPX）通过控制过氧化氢的积累来调节氧化应激。目的本研究旨在通过系统回顾和荟萃分析评估AD患者GPX活性。方法按照PRISMA指南，从四个电子数据库中检索数据，包括截至2024年12月发表的队列和病例对照研究。使用RevMan进行统计分析，并使用Newcastle-Ottawa量表评估偏倚风险。结果共收集科学论文1999篇，其中30篇被纳入系统综述；20例纳入meta分析。在红细胞、血浆和死后脑等不同组织中测定GPX活性。分析表明，在大多数研究中，与健康对照相比，AD患者的红细胞和血浆GPX活性受到抑制。结论分析表明，在大多数纳入的研究中，AD患者的GPX活性低于健康对照组。需要更详细的研究来更好地评估GPX活性对ad相关认知障碍和氧化应激的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Alzheimer's Disease 医学-神经科学

CiteScore

6.40

自引率

7.50%

发文量

1327

审稿时长

2 months

期刊介绍： The Journal of Alzheimer''s Disease (JAD) is an international multidisciplinary journal to facilitate progress in understanding the etiology, pathogenesis, epidemiology, genetics, behavior, treatment and psychology of Alzheimer''s disease. The journal publishes research reports, reviews, short communications, hypotheses, ethics reviews, book reviews, and letters-to-the-editor. The journal is dedicated to providing an open forum for original research that will expedite our fundamental understanding of Alzheimer''s disease.