Anti-neurodegenerative treatment in Alzheimer's disease: Multifaceted mechanisms of action of berberine.

IF 0.9 4区医学 Q4 PHARMACOLOGY & PHARMACY

International journal of clinical pharmacology and therapeutics Pub Date : 2025-06-02 DOI:10.5414/CP204725

Dandan Song, Congmin Zhang

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引用次数: 0

Abstract

Background: Berberine, a traditional Chinese medicine, has demonstrated significant therapeutic influences in treating diabetes, obesity, and diarrhea, among other conditions. It has exhibited potential therapeutic benefits for various neurodegenerative diseases, namely, Alzheimer's disease (AD), Huntington's disease (HD), and Parkinson's disease (PD).

Aims: This study aims to elucidate the mechanism behind berberine pharmacological action in treating AD.

Materials and methods: We search the articles published in PubMed and CNKI and summarize the mechanism of berberine in AD.

Results: In recent years, as research into the pharmacology of berberine has deepened, researchers have discovered its strong neuroprotective properties. The ability of berberine to enhance cognitive function is thought to result from inhibiting the spread of AD-related proteins, reducing oxidative stress and inflammation, increasing choline levels, and regulating autophagy.

Conclusion: This review explores the latest research on berberine in AD, suggesting that berberine and its analogs may offer a promising new approach to treating the condition.

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阿尔茨海默病的抗神经退行性治疗：黄连素的多方面作用机制。

背景：小檗碱是一种传统中药，在治疗糖尿病、肥胖、腹泻等疾病方面具有显著的疗效。它对各种神经退行性疾病，即阿尔茨海默病（AD）、亨廷顿病（HD）和帕金森病（PD）显示出潜在的治疗效果。目的：本研究旨在阐明小檗碱治疗AD的药理作用机制。材料与方法：检索PubMed和CNKI上发表的文章，总结小檗碱治疗AD的作用机制。结果：近年来，随着对小檗碱药理研究的深入，研究人员发现其具有较强的神经保护作用。小檗碱增强认知功能的能力被认为是通过抑制ad相关蛋白的传播、减少氧化应激和炎症、增加胆碱水平和调节自噬来实现的。结论：本文综述了小檗碱在AD中的最新研究进展，提示小檗碱及其类似物可能是治疗AD的新途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International journal of clinical pharmacology and therapeutics 医学-药学

CiteScore

1.70

自引率

12.50%

发文量

116

审稿时长

4-8 weeks

期刊介绍： The International Journal of Clinical Pharmacology and Therapeutics appears monthly and publishes manuscripts containing original material with emphasis on the following topics: Clinical trials, Pharmacoepidemiology - Pharmacovigilance, Pharmacodynamics, Drug disposition and Pharmacokinetics, Quality assurance, Pharmacogenetics, Biotechnological drugs such as cytokines and recombinant antibiotics. Case reports on adverse reactions are also of interest.