Global, regional, and national burden of lower respiratory infections and chronic obstructive pulmonary disease, 1990-2021: a systematic analysis from the global burden of disease study 2021.

IF 5.4 2区医学 Q1 INFECTIOUS DISEASES

Infection Pub Date : 2025-06-02 DOI:10.1007/s15010-025-02566-0

Yi-Yuan Wang, Jing Wang, Zhang-Wei Lu, Qian-Qian Zhou, Yang-Guang Cao, Yu-Jie Du, Xue Jin, Bao-Zhu Li

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引用次数: 0

Abstract

Purpose: This study evaluates the global burden of lower respiratory infections (LRIs) and chronic obstructive pulmonary disease (COPD), focusing on their combined impact across age groups and regions.

Methods: Data from 204 countries were analyzed using spatiotemporal Gaussian process regression to estimate LRI and COPD incidence, prevalence, and disability-adjusted life years (DALYs). Age-standardized ratios (ASR) and the Socio-Demographic Index (SDI) were used to compare disease burdens, with trends assessed via linear regression and restricted cubic spline models.

Results: In 2021, COPD and LRI caused 360 million cases and 5.9 million deaths, with the highest burden in low-SDI regions. COPD remained the fourth leading cause of death, while LRI dropped to seventh.

Conclusion: The bidirectional link between LRI and COPD exacerbates disease progression, disproportionately affecting low-income regions and aging populations. Addressing disparities in healthcare access, improving vaccines, and strengthening public health infrastructure are critical to reducing the global burden of these diseases.

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1990-2021年全球、区域和国家下呼吸道感染和慢性阻塞性肺病负担：来自2021年全球疾病负担研究的系统分析

目的：本研究评估下呼吸道感染（LRIs）和慢性阻塞性肺疾病（COPD）的全球负担，重点关注它们在不同年龄组和地区的综合影响。方法：使用时空高斯过程回归分析来自204个国家的数据，以估计LRI和COPD的发病率、患病率和残疾调整生命年（DALYs）。使用年龄标准化比率（ASR）和社会人口指数（SDI）比较疾病负担，并通过线性回归和限制三次样条模型评估趋势。结果：2021年，COPD和LRI造成3.6亿例病例，590万例死亡，低sdi地区负担最重。COPD仍然是第四大死因，而LRI则降至第七位。结论：LRI与COPD之间的双向联系加剧了疾病进展，对低收入地区和老龄化人群的影响尤为严重。解决在获得保健服务方面的差距、改进疫苗和加强公共卫生基础设施对于减轻这些疾病的全球负担至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Infection 医学-传染病学

CiteScore

12.50

自引率

1.30%

发文量

224

审稿时长

6-12 weeks

期刊介绍： Infection is a journal dedicated to serving as a global forum for the presentation and discussion of clinically relevant information on infectious diseases. Its primary goal is to engage readers and contributors from various regions around the world in the exchange of knowledge about the etiology, pathogenesis, diagnosis, and treatment of infectious diseases, both in outpatient and inpatient settings. The journal covers a wide range of topics, including: Etiology: The study of the causes of infectious diseases. Pathogenesis: The process by which an infectious agent causes disease. Diagnosis: The methods and techniques used to identify infectious diseases. Treatment: The medical interventions and strategies employed to treat infectious diseases. Public Health: Issues of local, regional, or international significance related to infectious diseases, including prevention, control, and management strategies. Hospital Epidemiology: The study of the spread of infectious diseases within healthcare settings and the measures to prevent nosocomial infections. In addition to these, Infection also includes a specialized "Images" section, which focuses on high-quality visual content, such as images, photographs, and microscopic slides, accompanied by brief abstracts. This section is designed to highlight the clinical and diagnostic value of visual aids in the field of infectious diseases, as many conditions present with characteristic clinical signs that can be diagnosed through inspection, and imaging and microscopy are crucial for accurate diagnosis. The journal's comprehensive approach ensures that it remains a valuable resource for healthcare professionals and researchers in the field of infectious diseases.