Benefit of Topical Haemocoagulase Solution Application in Tonsillectomy: A Double-Blinded Study

IF 1.5 4区医学 Q2 OTORHINOLARYNGOLOGY

Clinical Otolaryngology Pub Date : 2025-06-02 DOI:10.1111/coa.14330

Raadhika Shree, Meenakshi Srinivasan

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引用次数: 0

Abstract

Aim

This study aims to evaluate the benefit of topical haemocoagulase application during tonsillectomy in diminishing the operation time and intraoperative blood loss, as well as postoperative healing effects.

Methods

A randomised controlled trial was conducted including 60 patients undergoing tonsillectomy with or without adenoidectomy. The patients were randomly assigned into two groups of 30 each: the topical haemocoagulase applied in the tonsillectomy procedure as Group A (n = 30) (interventional group) and patients undergoing tonsillectomy using a conventional saline pressure pack as Group B (n = 30) (control group). After obtaining informed and written consent from the study population, patients were categorised into Group A and Group B through randomisation. Outcome measures evaluated included operation time, intraoperative blood loss, slough formation and clearance rate, postoperative pain and feeding habits. Data analysis was performed using SPSS version 19, employing descriptive statistics, Shapiro–Wilk tests for normality, independent t-tests for normally distributed data and chi-square tests for categorical variables, with statistical significance set at p < 0.05.

Results

Results revealed that Group A had significantly reduced operation times (p < 0.001), less intraoperative blood loss, faster slough clearance, and improved postoperative feeding habits compared to Group B.

Conclusion

The Topical haemocoagulase is a safe, effective and cost-efficient adjunct in tonsillectomy, offering significant advantages in surgical efficiency and postoperative recovery. Its ease of application and affordability make it a practical addition to routine surgical practice, benefiting both patients and healthcare providers. This study underscores the potential of haemocoagulase to enhance surgical outcomes and improve the overall quality of care in tonsillectomy procedures.

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局部应用凝血酶溶液在扁桃体切除术中的益处：一项双盲研究。

目的：本研究旨在评价扁桃体切除术中局部应用凝血酶对减少手术时间和术中出血量以及术后愈合效果的益处。方法：对60例扁桃体切除术合并或不合并腺样体切除术的患者进行随机对照试验。将患者随机分为两组，每组30人：A组（n = 30）（介入性组）和B组（n = 30）（对照组），分别为扁桃体切除术中应用局部凝血酶的患者。在获得研究人群的知情和书面同意后，通过随机分组将患者分为A组和B组。评估的结果包括手术时间、术中出血量、结痂形成和清除率、术后疼痛和喂养习惯。数据分析采用SPSS 19版，采用描述性统计、Shapiro-Wilk正态检验、正态分布独立t检验、分类变量卡方检验，统计学显著性设为p。结果：A组手术次数显著减少(p)。局部凝血酶在扁桃体切除术中是一种安全、有效、经济的辅助手段，在手术效率和术后恢复方面具有显著优势。它易于应用和负担得起，使其成为常规手术实践的实用补充，使患者和医疗保健提供者受益。本研究强调了凝血酶在扁桃体切除术中提高手术效果和整体护理质量的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Otolaryngology 医学-耳鼻喉科学

CiteScore

4.00

自引率

4.80%

发文量

106

审稿时长

>12 weeks

期刊介绍： Clinical Otolaryngology is a bimonthly journal devoted to clinically-oriented research papers of the highest scientific standards dealing with: current otorhinolaryngological practice audiology, otology, balance, rhinology, larynx, voice and paediatric ORL head and neck oncology head and neck plastic and reconstructive surgery continuing medical education and ORL training The emphasis is on high quality new work in the clinical field and on fresh, original research. Each issue begins with an editorial expressing the personal opinions of an individual with a particular knowledge of a chosen subject. The main body of each issue is then devoted to original papers carrying important results for those working in the field. In addition, topical review articles are published discussing a particular subject in depth, including not only the opinions of the author but also any controversies surrounding the subject. • Negative/null results In order for research to advance, negative results, which often make a valuable contribution to the field, should be published. However, articles containing negative or null results are frequently not considered for publication or rejected by journals. We welcome papers of this kind, where appropriate and valid power calculations are included that give confidence that a negative result can be relied upon.