Functional Brain Abnormalities in Patients With Accommodative Asthenopia: A Resting-State fMRI Study

IF 2.3 4区医学 Q3 CLINICAL NEUROLOGY

Journal of Neuroimaging Pub Date : 2025-06-02 DOI:10.1111/jon.70059

Xiaoli Lv, Wenli Tan, Ying Yu, Yu Shao, Jinhua Tao, Wanhong Miao, Pingping Yu, Yilei Chen

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引用次数: 0

Abstract

Background and Purpose

Excessive electronic device use has intensified visual workload, resulting in accommodative asthenopia (AA). Our previous functional MRI (fMRI) studies linked abnormal brain function to AA, prompting this resting-state fMRI study to explore local and global brain activity changes.

Methods

We recruited 33 healthy controls and 44 patients with AA, analyzing regional brain function via coherent regional homogeneity (Cohe-ReHo) and amplitude of low-frequency fluctuation (ALFF)/fractional ALFF (fALFF). Group independent component analysis (gICA) extracted independent components (ICs) for spatial comparison, and static/dynamic functional network connectivity (sFNC/dFNC) assessed subnetwork interactions.

Results

Patients with AA had increased ALFF in regions of the right cerebellum 9, superior lobe of the right cerebellum, left cerebellum 8, left cerebellum 9, and left brainstem; there were negative regions in the frontal lobe (also the same area found in fALFF values) and the right postcentral gyrus. Cohe-ReHo was elevated in the inferior lobes of the bilateral cerebellum and left caudate nucleus but reduced in the left median cingulate, paracingulate gyri, and right precentral gyrus. Correlation analysis among Cohe-ReHo, ALFF/fALFF values, and asthenopia survey scores showed that the correlation had no statistical significance. The gICA revealed that the spatial distribution of ICs showed no difference. The results of sFNC and dFNC analysis showed that there was no difference.

Conclusions

Patients with AA had regional brain dysfunction. In the analysis of brain subnetworks, there was no difference between the groups in terms of the spatial organization of subnetworks or the static and dynamic connectivity between subnetworks.

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适应性弱视患者脑功能异常：静息状态fMRI研究

背景与目的过度使用电子设备会加重视觉负荷，导致适应性弱视。我们之前的功能MRI （fMRI）研究将异常的脑功能与AA联系起来，促使这项静息状态fMRI研究探索局部和全局脑活动变化。方法采用相干区域均匀性（Cohe-ReHo）和低频波动幅度(ALFF)/分数ALFF （fALFF）分析脑区域功能。群独立分量分析（gICA）提取独立分量（ic）进行空间比较，静态/动态功能网络连通性（sFNC/dFNC）评估子网相互作用。结果AA患者在右小脑9、右小脑上叶、左小脑8、左小脑9、左脑干等区域ALFF增高；额叶（与fALFF值相同的区域）和右侧中央后回有负性区域。双侧小脑下叶和左侧尾状核的Cohe-ReHo升高，而左侧扣带正中回、扣带副回和右侧中央前回的Cohe-ReHo降低。Cohe-ReHo值、ALFF/fALFF值与视疲劳调查评分的相关分析显示相关性无统计学意义。gICA分析结果显示，各地区ic的空间分布无明显差异。sFNC和dFNC分析结果显示无差异。结论AA患者存在区域性脑功能障碍。在大脑子网的分析中，在子网的空间组织和子网之间的静态和动态连通性方面，各组之间没有差异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Neuroimaging 医学-核医学

CiteScore

4.70

自引率

0.00%

发文量

117

审稿时长

6-12 weeks

期刊介绍： Start reading the Journal of Neuroimaging to learn the latest neurological imaging techniques. The peer-reviewed research is written in a practical clinical context, giving you the information you need on: MRI CT Carotid Ultrasound and TCD SPECT PET Endovascular Surgical Neuroradiology Functional MRI Xenon CT and other new and upcoming neuroscientific modalities.The Journal of Neuroimaging addresses the full spectrum of human nervous system disease, including stroke, neoplasia, degenerating and demyelinating disease, epilepsy, tumors, lesions, infectious disease, cerebral vascular arterial diseases, toxic-metabolic disease, psychoses, dementias, heredo-familial disease, and trauma.Offering original research, review articles, case reports, neuroimaging CPCs, and evaluations of instruments and technology relevant to the nervous system, the Journal of Neuroimaging focuses on useful clinical developments and applications, tested techniques and interpretations, patient care, diagnostics, and therapeutics. Start reading today!