A Novel All-Solid-State Levocetirizine-Selective Potentiometric Microsensor

IF 4.3 2区综合性期刊 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC

IEEE Sensors Journal Pub Date : 2025-04-29 DOI:10.1109/JSEN.2025.3563624

Nurşen Dere

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引用次数: 0

Abstract

In this study, a novel all-solid-state potentiometric microsensor was developed for the selective and sensitive determination of levocetirizine dihydrochloride (LEV.2HCl) in pharmaceutical drug samples. For this purpose; levocetirizine-tetraphenylborate (LEV-TPB) ion-pair was synthesized using LEV.2HCl and sodium tetraphenylborate (NaTPB) and the microsensor was developed by using this ion-pair as an ionophore in the structure of the microsensor. The optimum membrane composition of the levocetirizine-selective (LEV-selective) microsensor was determined and the potentiometric performance characteristics were investigated. The detection limit of the proposed microsensor was calculated as

$3.5\times 10^{-{7}}$

$\mathrm{mol.L}^{-{1}}$

. The response time of the microsensor was significantly short (

$\le 10$

s). The microsensor showed a super-Nernstian response with a slope of

$59.9\pm 0.6$

mV (

${R}^{{2}}$

: 0.9991) over a wide concentration range of

$10^{-{6}}- 10^{-{2}}$

$\mathrm{mol.L}^{-{1}}$

for LEV.2HCl solutions over seven weeks and no significant drift in potentials. The microsensor was determined to have optimum performance in the pH range of 4.0–8.0. The microsensor was successfully used to determine levocetirizine in pharmaceutical samples. The results were statistically compared with the UV-Vis spectroscopy method. The obtained potentiometric results were in good harmony with the results obtained by the UV-Vis spectroscopy method at a confidence level of 95%.

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一种新型全固态左西替利嗪选择性电位微传感器

本研究建立了一种新型全固态电位微传感器，用于药物样品中盐酸左西替利嗪（LEV.2HCl）的选择性和敏感性测定。为此目的；以LEV.2HCl和四苯基硼酸钠（NaTPB）为原料合成了左西替利嗪-四苯基硼酸钠（LEV-TPB）离子对，并利用该离子对作为微传感器结构中的离子载体，研制了微传感器。确定了左西替利嗪选择性（LEV-selective）微传感器的最佳膜组成，并对其电位特性进行了研究。该微传感器的检出限计算为$3.5\乘以10^{-{7}}$ $\ mathm {mol。L} ^{-{1}} $。微传感器的响应时间显著缩短（$ $ 10$ s）。在10^{-{6}}- 10^{-{2}}$ $\ mathm {mol的宽浓度范围内，微传感器的响应斜率为59.9\pm 0.6$ mV （${R}^{{2}}$: 0.9991）。L}^{-{1}}$用于七周内的LEV.2HCl溶液，电位无明显漂移。结果表明，微传感器在pH值为4.0 ~ 8.0的范围内性能最佳。该微传感器成功地用于药物样品中左西替利嗪的测定。结果与紫外可见光谱法进行了统计比较。所得电位法结果与紫外可见光谱法结果吻合较好，置信水平为95%。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

IEEE Sensors Journal 工程技术-工程：电子与电气

CiteScore

7.70

自引率

14.00%

发文量

2058

审稿时长

5.2 months

期刊介绍： The fields of interest of the IEEE Sensors Journal are the theory, design , fabrication, manufacturing and applications of devices for sensing and transducing physical, chemical and biological phenomena, with emphasis on the electronics and physics aspect of sensors and integrated sensors-actuators. IEEE Sensors Journal deals with the following: -Sensor Phenomenology, Modelling, and Evaluation -Sensor Materials, Processing, and Fabrication -Chemical and Gas Sensors -Microfluidics and Biosensors -Optical Sensors -Physical Sensors: Temperature, Mechanical, Magnetic, and others -Acoustic and Ultrasonic Sensors -Sensor Packaging -Sensor Networks -Sensor Applications -Sensor Systems: Signals, Processing, and Interfaces -Actuators and Sensor Power Systems -Sensor Signal Processing for high precision and stability (amplification, filtering, linearization, modulation/demodulation) and under harsh conditions (EMC, radiation, humidity, temperature); energy consumption/harvesting -Sensor Data Processing (soft computing with sensor data, e.g., pattern recognition, machine learning, evolutionary computation; sensor data fusion, processing of wave e.g., electromagnetic and acoustic; and non-wave, e.g., chemical, gravity, particle, thermal, radiative and non-radiative sensor data, detection, estimation and classification based on sensor data) -Sensors in Industrial Practice