Nanosensing for tramadol detection: Innovative opioid analysis

IF 3.2 3区医学 Q2 MEDICAL LABORATORY TECHNOLOGY

Clinica Chimica Acta Pub Date : 2025-06-02 DOI:10.1016/j.cca.2025.120414

Ilghar Zeinaly , Ali Ahmadalipour , Mohammad Mahdi Heidari , Shahab Masoumi , Arash Mohagheghi , Ahmad Mobed

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Abstract

Tramadol, a widely used analgesic, plays a significant role in pain management but poses risks of misuse and addiction, necessitating accurate detection methods. Traditional analytical techniques for opioid determination, such as chromatography and mass spectrometry, often face limitations, including lengthy processing times, high costs, and the need for specialized equipment. In contrast, nanosensing technologies have emerged as innovative approaches for the sensitive and rapid detection of tramadol at the nanoscale. Over the past decade, extensive advancements in nanosensor development have demonstrated their potential to overcome the limitations of conventional methods. This paper aims to introduce and discuss recently developed nanosensors specifically designed for tramadol detection, highlighting their significance in pharmacology, forensic medicine, and point-of-care (POC) applications. By providing enhanced sensitivity, specificity, and real-time analysis, these nanosensing techniques signify a groundbreaking advancement in the efficient monitoring and management of tramadol usage.

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曲马多检测的纳米传感：创新的阿片分析

曲马多是一种广泛使用的镇痛药，在疼痛治疗中起着重要作用，但存在滥用和成瘾的风险，需要准确的检测方法。阿片类药物测定的传统分析技术，如色谱法和质谱法，往往面临局限性，包括处理时间长，成本高，需要专门的设备。相比之下，纳米传感技术已经成为在纳米尺度上对曲马多进行敏感和快速检测的创新方法。在过去的十年中，纳米传感器的广泛发展已经证明了它们克服传统方法局限性的潜力。本文旨在介绍和讨论最近开发的专门用于曲马多检测的纳米传感器，强调它们在药理学，法医学和护理点（POC）应用中的意义。通过提供增强的灵敏度，特异性和实时分析，这些纳米传感技术标志着曲马多使用的有效监测和管理的突破性进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinica Chimica Acta 医学-医学实验技术

CiteScore

10.10

自引率

2.00%

发文量

1268

审稿时长

23 days

期刊介绍： The Official Journal of the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) Clinica Chimica Acta is a high-quality journal which publishes original Research Communications in the field of clinical chemistry and laboratory medicine, defined as the diagnostic application of chemistry, biochemistry, immunochemistry, biochemical aspects of hematology, toxicology, and molecular biology to the study of human disease in body fluids and cells. The objective of the journal is to publish novel information leading to a better understanding of biological mechanisms of human diseases, their prevention, diagnosis, and patient management. Reports of an applied clinical character are also welcome. Papers concerned with normal metabolic processes or with constituents of normal cells or body fluids, such as reports of experimental or clinical studies in animals, are only considered when they are clearly and directly relevant to human disease. Evaluation of commercial products have a low priority for publication, unless they are novel or represent a technological breakthrough. Studies dealing with effects of drugs and natural products and studies dealing with the redox status in various diseases are not within the journal''s scope. Development and evaluation of novel analytical methodologies where applicable to diagnostic clinical chemistry and laboratory medicine, including point-of-care testing, and topics on laboratory management and informatics will also be considered. Studies focused on emerging diagnostic technologies and (big) data analysis procedures including digitalization, mobile Health, and artificial Intelligence applied to Laboratory Medicine are also of interest.