Creatine and cellular senescence: from molecular pathways to populational health

IF 4.3
Sergej M. Ostojic , Viktória Prémusz , Pongrác Ács
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引用次数: 0

Abstract

Emerging evidence suggests that creatine, a naturally occurring amino acid derivative and conditionally essential nutrient, may modulate cellular senescence through mechanisms such as enhancing cellular energy homeostasis, mitigating oxidative stress, and influencing key signaling pathways implicated in aging processes. This review critically evaluates the current body of research, highlights existing gaps in the mechanistic understanding, and emphasizes the importance of targeted studies to further delineate creatine's role in cellular senescence and age-associated dysfunctions. By integrating perspectives from molecular biology, gerontology, and applied physiology, this paper aims to advance the understanding of creatine-based strategies as potential interventions for promoting healthy aging and preventing senescence-associated conditions.
肌酸与细胞衰老:从分子途径到人群健康
越来越多的证据表明,肌酸作为一种天然存在的氨基酸衍生物和有条件必需营养素,可能通过增强细胞能量稳态、减轻氧化应激和影响衰老过程中涉及的关键信号通路等机制来调节细胞衰老。这篇综述批判性地评估了目前的研究,强调了在机制理解上存在的差距,并强调了有针对性的研究的重要性,以进一步描述肌酸在细胞衰老和年龄相关功能障碍中的作用。通过整合分子生物学、老年学和应用生理学的观点,本文旨在促进对肌酸为基础的策略作为促进健康衰老和预防衰老相关疾病的潜在干预措施的理解。
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来源期刊
Experimental gerontology
Experimental gerontology Ageing, Biochemistry, Geriatrics and Gerontology
CiteScore
6.70
自引率
0.00%
发文量
0
审稿时长
66 days
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