Synthesis of Lipophilic Quinazolinone Template as Pollutant's Scavenger in Aqueous System and Evaluation of Its Anti-Yeast Activity

Abstract

Non-polymeric small amphiphiles have attained a significant role in various applications due to their defined and consistent molecular assembly and hydrophobic/lipophilic balance. Synthesized Amphiphiles 2-(5-(bis(dodecylthio)methyl)-2-hydroxyphenyl)quinazolin-4(3H)-one (Q-C12) has been recognized as new amphiphiles. The structurally Q-C12 has a fluorescent quinazolinone moiety attached with two sulfur centers and two long alkyl chains. The structural uniqueness of Q-C12 for the presence of sulfur-based alkyl chain backbone makes it selective towards the detection of mercury (Hg²⁺) ions, followed by the scavenging from the aqueous system. It also shows its ability to detect and bind with diethyl chlorophosphate (DCP), a toxic stimulant for nerve agents, using its fluorescence efficacy. Each observation has been well studied using NMR, fluorescence, and DLS analysis. Further, Q-C12 behaves very effectively as an anti-yeast agent. The yeast cell imaging study has been captured against yeast Pichia sp. strain KG2 using Fluorescent Q-C12. The development of low-cost and functional amphiphile, Q-C12 claims great promise for environmental monitoring, advanced material, and biomedical innovations, and also offers a multifunctional approach to addressing key challenges in pollution control and healthcare.