Electrochemical detection of tetracycline using Cu-MOF functionalised screen-printed electrodes.

Abstract

This study offers a novel approach to fabricating an electrochemical sensor based on a screen-printed electrode (SPE) modified with a monometallic copper metal-organic framework (Cu-MOF) for detecting tetracycline. Despite tetracycline is an antibiotic used extensively in both human and animal healthcare, overuse of the drug has polluted the environment and caused antibiotic resistance. To protect the public's health and stop the development of resistant bacterial strains, it is essential to detect tetracycline in the supply of food and water. Furthermore, Cu-MOF was synthesized by a solvothermal technique utilizing terephthalic acid as the building block. Several characterization examinations verified the synthesis of the MOF. Because of the metal synergism between Cu ions, the monometallic Cu-MOF showed strong tetracycline adsorption and electrocatalytic capabilities. For the tetracycline electro-determination, it was therefore used as the electrode material. Differential Pulse Voltammetry was employed in the electroanalysis, with a linearity range of 0.0001-100 µmol L^-1 and a detection limit as low as 1.007 µmol L^-1. The sensor was successfully applied to real-sample matrices, including tap water and RO water, demonstrating good recovery values ranging from 97.05 to 105.71%; the suggested sensor showed good recovery of the antibiotic that had been spiked.