Dirk Adolph, Xiao Chi Zhang, Tobias Teismann, Andre Wannemüller, Jürgen Margraf
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引用次数: 0
Abstract
Respiratory sinus arrhythmia (RSA) reflects the activity of a cortico-limbic control system, enabling the flexible regulation of cardiac output via the parasympathetic nervous system. We assessed two markers of RSA, that is resting RSA (rRSA) and RSA reactivity (ΔRSA) and evaluated their common and distinct role for regulating emotional reactivity across depressive and anxiety disorders and their treatments. We recruited samples of healthy controls and patients with anxiety and depressive disorders, assessed rRSA during baseline and ΔRSA as RSA change from baseline to viewing emotional films. Patients then underwent disorder-specific cognitive behavior therapy. Although both patient groups exhibited lower rRSA than controls, depression-but not anxiety-symptomatology was transdiagnostically associated with less rRSA and ΔRSA. Complementing these depression-specific results, better ΔRSA predicted better treatment outcome in depression, but not anxiety. Our data confirm RSA as a transdiagnostic marker for mood and anxiety, support recent attempts toward transdiagnostic, dimensional classification systems (HiToP, RDoC) and provide evidence for a more robust association of RSA with depression symptomatology and treatment. This renders rRSA and ΔRSA potential markers to assess common and distinct mechanisms associated with depression and anxiety.
期刊介绍:
Founded in 1964, Psychophysiology is the most established journal in the world specifically dedicated to the dissemination of psychophysiological science. The journal continues to play a key role in advancing human neuroscience in its many forms and methodologies (including central and peripheral measures), covering research on the interrelationships between the physiological and psychological aspects of brain and behavior. Typically, studies published in Psychophysiology include psychological independent variables and noninvasive physiological dependent variables (hemodynamic, optical, and electromagnetic brain imaging and/or peripheral measures such as respiratory sinus arrhythmia, electromyography, pupillography, and many others). The majority of studies published in the journal involve human participants, but work using animal models of such phenomena is occasionally published. Psychophysiology welcomes submissions on new theoretical, empirical, and methodological advances in: cognitive, affective, clinical and social neuroscience, psychopathology and psychiatry, health science and behavioral medicine, and biomedical engineering. The journal publishes theoretical papers, evaluative reviews of literature, empirical papers, and methodological papers, with submissions welcome from scientists in any fields mentioned above.