Respiratory Sinus Arrhythmia-Common and Distinct Mechanisms of Emotional Adjustment in the Depressive and Anxiety Disorders Spectrum?

IF 2.9 2区 心理学 Q2 NEUROSCIENCES
Dirk Adolph, Xiao Chi Zhang, Tobias Teismann, Andre Wannemüller, Jürgen Margraf
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引用次数: 0

Abstract

Respiratory sinus arrhythmia (RSA) reflects the activity of a cortico-limbic control system, enabling the flexible regulation of cardiac output via the parasympathetic nervous system. We assessed two markers of RSA, that is resting RSA (rRSA) and RSA reactivity (ΔRSA) and evaluated their common and distinct role for regulating emotional reactivity across depressive and anxiety disorders and their treatments. We recruited samples of healthy controls and patients with anxiety and depressive disorders, assessed rRSA during baseline and ΔRSA as RSA change from baseline to viewing emotional films. Patients then underwent disorder-specific cognitive behavior therapy. Although both patient groups exhibited lower rRSA than controls, depression-but not anxiety-symptomatology was transdiagnostically associated with less rRSA and ΔRSA. Complementing these depression-specific results, better ΔRSA predicted better treatment outcome in depression, but not anxiety. Our data confirm RSA as a transdiagnostic marker for mood and anxiety, support recent attempts toward transdiagnostic, dimensional classification systems (HiToP, RDoC) and provide evidence for a more robust association of RSA with depression symptomatology and treatment. This renders rRSA and ΔRSA potential markers to assess common and distinct mechanisms associated with depression and anxiety.

呼吸窦性心律失常——抑郁和焦虑障碍谱系中常见和独特的情绪调节机制?
呼吸性窦性心律失常(RSA)反映了皮质-边缘控制系统的活动,通过副交感神经系统灵活调节心输出量。我们评估了RSA的两个标记,即静息RSA (rRSA)和RSA反应性(ΔRSA),并评估了它们在调节抑郁和焦虑障碍的情绪反应及其治疗中的共同和独特作用。我们招募了健康对照和患有焦虑和抑郁障碍的患者,评估了基线期间的rRSA和ΔRSA期间RSA从基线到观看情感电影的变化。然后,患者接受了针对障碍的认知行为治疗。尽管两组患者均表现出较低的rRSA,但经诊断,抑郁(而非焦虑)症状与较低的rRSA和ΔRSA相关。与这些抑郁症特异性结果相辅相成的是,更好的ΔRSA预测抑郁症的治疗效果更好,但不包括焦虑。我们的数据证实了RSA是一种情绪和焦虑的跨诊断标志物,支持了最近对跨诊断、维度分类系统(HiToP、RDoC)的尝试,并为RSA与抑郁症状和治疗之间更强有力的关联提供了证据。这使得rRSA和ΔRSA成为评估与抑郁和焦虑相关的常见和独特机制的潜在标记。
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来源期刊
Psychophysiology
Psychophysiology 医学-神经科学
CiteScore
6.80
自引率
8.10%
发文量
225
审稿时长
2 months
期刊介绍: Founded in 1964, Psychophysiology is the most established journal in the world specifically dedicated to the dissemination of psychophysiological science. The journal continues to play a key role in advancing human neuroscience in its many forms and methodologies (including central and peripheral measures), covering research on the interrelationships between the physiological and psychological aspects of brain and behavior. Typically, studies published in Psychophysiology include psychological independent variables and noninvasive physiological dependent variables (hemodynamic, optical, and electromagnetic brain imaging and/or peripheral measures such as respiratory sinus arrhythmia, electromyography, pupillography, and many others). The majority of studies published in the journal involve human participants, but work using animal models of such phenomena is occasionally published. Psychophysiology welcomes submissions on new theoretical, empirical, and methodological advances in: cognitive, affective, clinical and social neuroscience, psychopathology and psychiatry, health science and behavioral medicine, and biomedical engineering. The journal publishes theoretical papers, evaluative reviews of literature, empirical papers, and methodological papers, with submissions welcome from scientists in any fields mentioned above.
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