Diet-induced inflammation and its association with sarcopenia in an Iranian population: a case-control study.

IF 2.4 3区医学 Q3 ENVIRONMENTAL SCIENCES

Journal of Health, Population, and Nutrition Pub Date : 2025-05-31 DOI:10.1186/s41043-025-00942-y

Neda Heidarzadeh-Esfahani, Sevda Eskandarzadeh, Marzieh Mahmoodi, Maede Makhtoomi, Seyyed Mohammad Alavi, Zainab Shateri, Nasrin Nasimi, Mehran Nouri, Mohammad Hossein Dabbaghmanesh

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引用次数: 0

Abstract

Background: Dietary intake, as one of the critical lifestyle risk factors, plays a crucial role in the risk of sarcopenia, potentially due to its anti-inflammatory properties. The objective of this study was to evaluate the association between the Dietary Inflammatory Index (DII) and the Dietary Inflammatory Score (DIS) with sarcopenia in an Iranian population.

Methods: In the present study, 80 participants with sarcopenia were included in the case group, and 80 non-sarcopenia participants were included in the control group, matched by gender. Sarcopenia was diagnosed according to the Asian Working Group on Sarcopenia (AWGS) guidelines. Additionally, dietary data obtained from a food frequency questionnaire were used to calculate participants' DIS and DII scores. The association between the DII and DIS and the odds ratio of sarcopenia was assessed by logistic regression in both crude and adjusted models.

Results: In the crude model, the odds of sarcopenia were significantly higher for each unit increase in DIS and DII scores (DIS: odds ratio (OR) = 1.221, 95% confidence interval (CI): 1.128-1.322; DII: OR = 1.271, 95% CI: 1.041-1.553). After adjusting for age, energy, and protein intake, higher odds of sarcopenia were observed for each unit increase in DIS score (OR = 1.129, 95% CI: 1.004-1.268). Similarly, higher odds of sarcopenia were seen for each unit increase in DII score after adjusting for potential confounders (OR = 1.269, 95% CI: 1.032-1.561).

Conclusions: In conclusion, this study found that greater adherence to the DII and DIS was associated with higher odds of sarcopenia in older adults.

Clinical trial number: Not applicable.

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伊朗人群中饮食引起的炎症及其与肌肉减少症的关系：一项病例对照研究

背景：饮食摄入作为关键的生活方式风险因素之一，在肌肉减少症的风险中起着至关重要的作用，可能是由于其抗炎特性。本研究的目的是评估伊朗人群中饮食炎症指数（DII）和饮食炎症评分（DIS）与肌肉减少症之间的关系。方法：本研究将80例肌肉减少症患者纳入病例组，80例非肌肉减少症患者纳入对照组，按性别匹配。骨骼肌减少症是根据亚洲骨骼肌减少症工作组（AWGS）指南诊断的。此外，从食物频率问卷中获得的饮食数据用于计算参与者的DIS和DII评分。在粗模型和调整模型中，通过logistic回归评估DII和DIS与肌肉减少症的优势比之间的关系。结果：在粗模型中，DIS和DII评分每增加一个单位，肌少症的发生率显著增高(DIS：比值比(OR) = 1.221, 95%可信区间（CI）： 1.128 ~ 1.322；Dii: or = 1.271, 95% ci: 1.041-1.553)。在调整了年龄、能量和蛋白质摄入后，DIS评分每增加一个单位，肌肉减少症的发生率就会增加（OR = 1.129, 95% CI: 1.004-1.268）。同样，在调整潜在混杂因素后，DII评分每增加一个单位，肌肉减少症的几率就会增加（OR = 1.269, 95% CI: 1.032-1.561）。结论：总之，本研究发现，老年人更坚持DII和DIS与更高的肌肉减少症发生率相关。临床试验号：不适用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Health, Population, and Nutrition 医学-公共卫生、环境卫生与职业卫生

CiteScore

2.20

自引率

0.00%

发文量

审稿时长

6 months

期刊介绍： Journal of Health, Population and Nutrition brings together research on all aspects of issues related to population, nutrition and health. The journal publishes articles across a broad range of topics including global health, maternal and child health, nutrition, common illnesses and determinants of population health.